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	Comments on: NASA study says deep space will cause cancer and destroy stomachs	</title>
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	<link>https://behindtheblack.com/behind-the-black/points-of-information/nasa-study-says-deep-space-will-cause-cancer-and-destroy-stomachs/</link>
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		<title>
		By: wayne		</title>
		<link>https://behindtheblack.com/behind-the-black/points-of-information/nasa-study-says-deep-space-will-cause-cancer-and-destroy-stomachs/#comment-1060083</link>

		<dc:creator><![CDATA[wayne]]></dc:creator>
		<pubDate>Fri, 05 Oct 2018 13:49:24 +0000</pubDate>
		<guid isPermaLink="false">https://behindtheblack.com/?p=54008#comment-1060083</guid>

					<description><![CDATA[NASA Talk - 
&quot;Spacecraft, Habitats and Radiation Protection&quot; 
2015 Langley Research Center
https://youtu.be/GIYdF7YlX3o?t=1005

cued to the relevant section:

&quot;Risk of exposure induced death must be kept below 3%, at a 95% confidence interval.&quot;]]></description>
			<content:encoded><![CDATA[<p>NASA Talk &#8211;<br />
&#8220;Spacecraft, Habitats and Radiation Protection&#8221;<br />
2015 Langley Research Center<br />
<a href="https://youtu.be/GIYdF7YlX3o?t=1005" rel="nofollow ugc">https://youtu.be/GIYdF7YlX3o?t=1005</a></p>
<p>cued to the relevant section:</p>
<p>&#8220;Risk of exposure induced death must be kept below 3%, at a 95% confidence interval.&#8221;</p>
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		<title>
		By: pzatchok		</title>
		<link>https://behindtheblack.com/behind-the-black/points-of-information/nasa-study-says-deep-space-will-cause-cancer-and-destroy-stomachs/#comment-1060052</link>

		<dc:creator><![CDATA[pzatchok]]></dc:creator>
		<pubDate>Thu, 04 Oct 2018 17:18:38 +0000</pubDate>
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					<description><![CDATA[It seems that the main researcher is more upset that a drug based cure for this damage has not been found than anything else. Like prevention. 



I have been following the development of Ex-Rad or ON 01210.Na for many years now.
https://en.wikipedia.org/wiki/Ex-Rad

Its not a wonder drug to fight cancer or radiation damage but it does work very well against specific damage. Mainly hematologic cancers and gastric cancers.

Its main problem is its not a cure but a only a preventative. So the person must continually take the drug and it only lasts about a week in the body.



This is the kind of drug that could benefit from a moon based research lab. A years worth of study of pigs taking the drug on the surface of the moon in an  unshielded dome. The humans could live in shielded domes. 
I don&#039;t think caring for pigs in a zero G environment like fLOP-G would work out well.


I never did like these studies where they administered huge doses of something over a short period of time to &quot;simulate&quot; exposure. They almost never directly relate to real life.]]></description>
			<content:encoded><![CDATA[<p>It seems that the main researcher is more upset that a drug based cure for this damage has not been found than anything else. Like prevention. </p>
<p>I have been following the development of Ex-Rad or ON 01210.Na for many years now.<br />
<a href="https://en.wikipedia.org/wiki/Ex-Rad" rel="nofollow ugc">https://en.wikipedia.org/wiki/Ex-Rad</a></p>
<p>Its not a wonder drug to fight cancer or radiation damage but it does work very well against specific damage. Mainly hematologic cancers and gastric cancers.</p>
<p>Its main problem is its not a cure but a only a preventative. So the person must continually take the drug and it only lasts about a week in the body.</p>
<p>This is the kind of drug that could benefit from a moon based research lab. A years worth of study of pigs taking the drug on the surface of the moon in an  unshielded dome. The humans could live in shielded domes.<br />
I don&#8217;t think caring for pigs in a zero G environment like fLOP-G would work out well.</p>
<p>I never did like these studies where they administered huge doses of something over a short period of time to &#8220;simulate&#8221; exposure. They almost never directly relate to real life.</p>
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		<title>
		By: Kirk		</title>
		<link>https://behindtheblack.com/behind-the-black/points-of-information/nasa-study-says-deep-space-will-cause-cancer-and-destroy-stomachs/#comment-1060050</link>

		<dc:creator><![CDATA[Kirk]]></dc:creator>
		<pubDate>Thu, 04 Oct 2018 17:03:21 +0000</pubDate>
		<guid isPermaLink="false">https://behindtheblack.com/?p=54008#comment-1060050</guid>

					<description><![CDATA[Found it: http://www.pnas.org/content/early/2018/09/26/1807522115
&lt;i&gt;Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine&lt;/i&gt;

Under: &lt;i&gt;Materials and Methods / Mouse Irradiation&lt;/i&gt;

&lt;i&gt;Wild-type mice (C57BL/6J; male, 6 to 8 wk old; n = 10) were irradiated (dose: 0.5 Gy) using a simulated space radiation source at the NASA Space Radiation Laboratory (NSRL), Brookhaven National Laboratory for iron (56Fe; energy: 1,000 MeV per nucleon; LET: 148 keV/μm) irradiation, and a 137Cs source was used for γ-ray (LET: 0.8 keV/μm) whole-body irradiation of mice. Mice were euthanized either 7 d, 60 d, or 12 mo after radiation exposure.&lt;/i&gt;

So while not explicitly stated, it appears that the entire dose (0.5 Gy = 50 rad, for those still used to cgs units) likely was given in a single short exposure.

I think the reason they do it this way is that it&#039;s cheaper to get access to a high rate source for a short period than to have continuous access to a lower rate source for a much longer period of time.  I would think that rate would be as important as total dose in these tests, but I&#039;ve not read any scholarly arguments on the subject.]]></description>
			<content:encoded><![CDATA[<p>Found it: <a href="http://www.pnas.org/content/early/2018/09/26/1807522115" rel="nofollow ugc">http://www.pnas.org/content/early/2018/09/26/1807522115</a><br />
<i>Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine</i></p>
<p>Under: <i>Materials and Methods / Mouse Irradiation</i></p>
<p><i>Wild-type mice (C57BL/6J; male, 6 to 8 wk old; n = 10) were irradiated (dose: 0.5 Gy) using a simulated space radiation source at the NASA Space Radiation Laboratory (NSRL), Brookhaven National Laboratory for iron (56Fe; energy: 1,000 MeV per nucleon; LET: 148 keV/μm) irradiation, and a 137Cs source was used for γ-ray (LET: 0.8 keV/μm) whole-body irradiation of mice. Mice were euthanized either 7 d, 60 d, or 12 mo after radiation exposure.</i></p>
<p>So while not explicitly stated, it appears that the entire dose (0.5 Gy = 50 rad, for those still used to cgs units) likely was given in a single short exposure.</p>
<p>I think the reason they do it this way is that it&#8217;s cheaper to get access to a high rate source for a short period than to have continuous access to a lower rate source for a much longer period of time.  I would think that rate would be as important as total dose in these tests, but I&#8217;ve not read any scholarly arguments on the subject.</p>
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		<title>
		By: Kirk		</title>
		<link>https://behindtheblack.com/behind-the-black/points-of-information/nasa-study-says-deep-space-will-cause-cancer-and-destroy-stomachs/#comment-1060049</link>

		<dc:creator><![CDATA[Kirk]]></dc:creator>
		<pubDate>Thu, 04 Oct 2018 16:47:23 +0000</pubDate>
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					<description><![CDATA[Several previous studies on the effects of simulated GCR have induced the expected dose from an extended mission, but at a much higher rate over a much shorter period of time, assuming that as long as the total dose matched, that was good enough.

The linked article says &lt;i&gt;a very low dose&lt;/i&gt; [of  iron ion radiation] &lt;i&gt;was delivered over the equivalent of a months-long period in deep space&lt;/i&gt; but doesn&#039;t give specifics.  Is the paper publicly available?]]></description>
			<content:encoded><![CDATA[<p>Several previous studies on the effects of simulated GCR have induced the expected dose from an extended mission, but at a much higher rate over a much shorter period of time, assuming that as long as the total dose matched, that was good enough.</p>
<p>The linked article says <i>a very low dose</i> [of  iron ion radiation] <i>was delivered over the equivalent of a months-long period in deep space</i> but doesn&#8217;t give specifics.  Is the paper publicly available?</p>
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