Researchers discover an anti-aging drug that extends the lives of rats 25%
Researchers have discovered that by blocking the increase of a certain protein within the body, they can not only extend the lives of rats by about 25%, the rats overall health in old age was improved significantly.
You can read the original paper here and the press release from the researchers here. From that press release:
After establishing IL11’s role in aging, the team demonstrated that by applying this anti-IL11 therapy in the same preclinical model, metabolism was improved. The mice shifted from generating white fat to beneficial brown fat. Brown fat breaks down blood sugar and fat molecules to help maintain body temperature and burn calories. The researchers also observed improved muscle function and overall better health in their study, as well as an increased lifespan by up to 5 per cent in both sexes.
Unlike other drugs known to inhibit specific pathways involved in aging, such as metformin and rapamycin, anti-IL11 therapy blocks multiple major signaling mechanisms that become dysfunctional with age, offering protection against cardio-metabolic diseases, age-related loss of muscle mass and strength as well as frailty. In addition to these externally observable changes, anti-IL11 therapy also reduced the rate of telomere shortening and preserved mitochondria’s health and ability to generate energy.
According the paper, this drug is now in early-stage clinical trials for fibrotic lung disease, but its benefits — as seen in these rat experiments — could turn out to be far greater, across the board.
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Researchers have discovered that by blocking the increase of a certain protein within the body, they can not only extend the lives of rats by about 25%, the rats overall health in old age was improved significantly.
You can read the original paper here and the press release from the researchers here. From that press release:
After establishing IL11’s role in aging, the team demonstrated that by applying this anti-IL11 therapy in the same preclinical model, metabolism was improved. The mice shifted from generating white fat to beneficial brown fat. Brown fat breaks down blood sugar and fat molecules to help maintain body temperature and burn calories. The researchers also observed improved muscle function and overall better health in their study, as well as an increased lifespan by up to 5 per cent in both sexes.
Unlike other drugs known to inhibit specific pathways involved in aging, such as metformin and rapamycin, anti-IL11 therapy blocks multiple major signaling mechanisms that become dysfunctional with age, offering protection against cardio-metabolic diseases, age-related loss of muscle mass and strength as well as frailty. In addition to these externally observable changes, anti-IL11 therapy also reduced the rate of telomere shortening and preserved mitochondria’s health and ability to generate energy.
According the paper, this drug is now in early-stage clinical trials for fibrotic lung disease, but its benefits — as seen in these rat experiments — could turn out to be far greater, across the board.
The support of my readers through the years has given me the freedom and ability to analyze objectively the ongoing renaissance in space, as well as the cultural changes -- for good or ill -- that are happening across America. Four years ago, just before the 2020 election I wrote that Joe Biden's mental health was suspect. Only in the past two weeks has the mainstream media decided to recognize that basic fact.
Fourteen years ago I wrote that SLS and Orion were a bad ideas, a waste of money, would be years behind schedule, and better replaced by commercial private enterprise. Even today NASA and Congress refuses to recognize this reality.
In 2020 when the world panicked over COVID I wrote that the panic was unnecessary, that the virus was apparently simply a variation of the flu, that masks were not simply pointless but if worn incorrectly were a health threat, that the lockdowns were a disaster and did nothing to stop the spread of COVID. Only in the past year have some of our so-called experts in the health field have begun to recognize these facts.
Your help allows me to do this kind of intelligent analysis. I take no advertising or sponsors, so my reporting isn't influenced by donations by established space or drug companies. Instead, I rely entirely on donations and subscriptions from my readers, which gives me the freedom to write what I think, unencumbered by outside influences.
Please consider supporting my work here at Behind the Black.
You can support me either by giving a one-time contribution or a regular subscription. There are five ways of doing so:
1. Zelle: This is the only internet method that charges no fees. All you have to do is use the Zelle link at your internet bank and give my name and email address (zimmerman at nasw dot org). What you donate is what I get.
2. Patreon: Go to my website there and pick one of five monthly subscription amounts, or by making a one-time donation.
3. A Paypal Donation:
5. Donate by check, payable to Robert Zimmerman and mailed to
Behind The Black
c/o Robert Zimmerman
P.O.Box 1262
Cortaro, AZ 85652
You can also support me by buying one of my books, as noted in the boxes interspersed throughout the webpage or shown in the menu above. And if you buy the books through the ebookit links, I get a larger cut and I get it sooner.
Democrats, Liberals and Leftist “progressives” are lining up for it!
Anti American Rats all.
Do you want a zombie apocalypse, because that’s how you get a zombie apocalypse.
I said being anti American rats they would be lined up for it, I did not say they should be given it.
With our luck, we’ll discover it works only on small mammals. That, or they’ll realize that blocking the protein has completely unforeseen side effects, like more cancer or constant pain.
If it’s too good to be true…
(This said, I’d love to be proven wrong! I could use a few more years in good health.)
If there ever was an argument for Congressional term limits this is it.