Tag Archives: MRI

MRI software bug invalidates 40,000 research papers

The uncertainty of science: A bug just discovered in the computer software used by MRIs to measure brain activity could invalidate 15 years of research and 40,000 science papers.

They tested the three most popular fMRI software packages for fMRI analysis – SPM, FSL, and AFNI – and while they shouldn’t have found much difference across the groups, the software resulted in false-positive rates of up to 70 percent. And that’s a problem, because as Kate Lunau at Motherboard points out, not only did the team expect to see an average false positive rate of just 5 percent, it also suggests that some results were so inaccurate, they could be indicating brain activity where there was none.

“These results question the validity of some 40,000 fMRI studies and may have a large impact on the interpretation of neuroimaging results,” the team writes in PNAS. The bad news here is that one of the bugs the team identified has been in the system for the past 15 years, which explains why so many papers could now be affected. [emphasis mine]

The research the article described is focused entirely on the problems the software causes for past research. It makes no mention of the problems this software bug might cause for actual medical diagnosis Was the treatment of any patients effected by this bug? It does not say.