Bioengineered heart samples on ISS confirm that weightlessness weakens and ages the heart
Using 48 bioengineered heart samples that spent 30 days on ISS in 2020, scientists have confirmed other research that showed weightlessness not only weakens the heart, it ages it as well.
In addition to losing strength, the heart muscle tissues in space developed irregular beating (arrhythmias)—disruptions that can cause a human heart to fail. Normally, the time between one beat of cardiac tissue and the next is about a second. This measure, in the tissues aboard the space station, grew to be nearly five times longer than those on Earth, although the time between beats returned nearly to normal when the tissues returned to Earth.
The scientists also found, in the tissues that went to space, that sarcomeres—the protein bundles in muscle cells that help them contract—became shorter and more disordered, a hallmark of human heart disease. In addition, energy-producing mitochondria in the space-bound cells grew larger, rounder and lost the characteristic folds that help the cells use and produce energy.
Finally …[t]he tissues at the space station showed increased gene production involved in inflammation and oxidative damage, also hallmarks of heart disease.
None of this is ground-breaking, as it confirms numerous other past studies. What it does do however is confirm that long-term weightlessness is not good for a person’s heart. Many studies have shown that these issues mostly go away once astronauts return to Earth, but for any journey to Mars, involving two years in weightlessness, this data suggests the health risks will be far higher.
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Using 48 bioengineered heart samples that spent 30 days on ISS in 2020, scientists have confirmed other research that showed weightlessness not only weakens the heart, it ages it as well.
In addition to losing strength, the heart muscle tissues in space developed irregular beating (arrhythmias)—disruptions that can cause a human heart to fail. Normally, the time between one beat of cardiac tissue and the next is about a second. This measure, in the tissues aboard the space station, grew to be nearly five times longer than those on Earth, although the time between beats returned nearly to normal when the tissues returned to Earth.
The scientists also found, in the tissues that went to space, that sarcomeres—the protein bundles in muscle cells that help them contract—became shorter and more disordered, a hallmark of human heart disease. In addition, energy-producing mitochondria in the space-bound cells grew larger, rounder and lost the characteristic folds that help the cells use and produce energy.
Finally …[t]he tissues at the space station showed increased gene production involved in inflammation and oxidative damage, also hallmarks of heart disease.
None of this is ground-breaking, as it confirms numerous other past studies. What it does do however is confirm that long-term weightlessness is not good for a person’s heart. Many studies have shown that these issues mostly go away once astronauts return to Earth, but for any journey to Mars, involving two years in weightlessness, this data suggests the health risks will be far higher.
The support of my readers through the years has given me the freedom and ability to analyze objectively the ongoing renaissance in space, as well as the cultural changes -- for good or ill -- that are happening across America. Four years ago, just before the 2020 election I wrote that Joe Biden's mental health was suspect. Only in the past two weeks has the mainstream media decided to recognize that basic fact.
Fourteen years ago I wrote that SLS and Orion were a bad ideas, a waste of money, would be years behind schedule, and better replaced by commercial private enterprise. Even today NASA and Congress refuses to recognize this reality.
In 2020 when the world panicked over COVID I wrote that the panic was unnecessary, that the virus was apparently simply a variation of the flu, that masks were not simply pointless but if worn incorrectly were a health threat, that the lockdowns were a disaster and did nothing to stop the spread of COVID. Only in the past year have some of our so-called experts in the health field have begun to recognize these facts.
Your help allows me to do this kind of intelligent analysis. I take no advertising or sponsors, so my reporting isn't influenced by donations by established space or drug companies. Instead, I rely entirely on donations and subscriptions from my readers, which gives me the freedom to write what I think, unencumbered by outside influences.
Please consider supporting my work here at Behind the Black.
You can support me either by giving a one-time contribution or a regular subscription. There are five ways of doing so:
1. Zelle: This is the only internet method that charges no fees. All you have to do is use the Zelle link at your internet bank and give my name and email address (zimmerman at nasw dot org). What you donate is what I get.
2. Patreon: Go to my website there and pick one of five monthly subscription amounts, or by making a one-time donation.
3. A Paypal Donation:
5. Donate by check, payable to Robert Zimmerman and mailed to
Behind The Black
c/o Robert Zimmerman
P.O.Box 1262
Cortaro, AZ 85652
You can also support me by buying one of my books, as noted in the boxes interspersed throughout the webpage or shown in the menu above. And if you buy the books through the ebookit links, I get a larger cut and I get it sooner.
We evolved to live in gravity. Whuttasurprise.
So based on this, are we doing tests to see how much gravity is needed in centrifuge? I mean if 10% gravity had 90% of the loss as 100% we could save a lot of money by not spinning hard enough to replicate earth gravity…
And the gravity “results” take nothing else into account. So they are basically worthless.
“This here tissue sample is identical to in vivo.” Old guy in charge of the interns rears back and lands a serious punch…
What I don’t understand is why do we keep running these studies if the result is the same every time. Are they hoping for a different outcome?
Until we have a centrifuge that can simulate different levels of gravity, these experiments should be put on pause and others conducted.
Joe, there’s no other reason to run the International Scam Station besides bad science.