Liver damage from weightlessness?
The uncertainty of science: Mice flown for almost two weeks on the last space shuttle mission in 2011 have shown evidence of the early symptoms of liver disease.
The mice spent time orbiting the Earth on the final space shuttle flight in 2011. Once they returned home, teams of scientists were allowed to share and study their internal organs.
Jonscher’s team found that spaceflight resulted in increased fat storage in the liver, comparing pair-fed mice on Earth to those on the shuttle. This was accompanied by a loss of retinol, an animal form of Vitamin A, and changes to levels of genes responsible for breaking down fats. As a result, mice showed signs of nonalcoholic fatty liver disease (NAFLD) and potential early indicators for the beginnings of fibrosis, which can be one of the more progressive consequences of NAFLD. “It generally takes a long time, months to years, to induce fibrosis in mice, even when eating an unhealthy diet,” Jonscher said. “If a mouse is showing nascent signs of fibrosis without a change in diet after 13 ½ days, what is happening to the humans?”
This result doesn’t prove that weightlessness causes liver damage. It only suggests that more research is needed, though the data from six month to year long missions suggest that the liver harm to humans is either non-existent or temporary.
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In 2020 when the world panicked over COVID I wrote that the panic was unnecessary, that the virus was apparently simply a variation of the flu, that masks were not simply pointless but if worn incorrectly were a health threat, that the lockdowns were a disaster and did nothing to stop the spread of COVID. Only in the past year have some of our so-called experts in the health field have begun to recognize these facts.
Your help allows me to do this kind of intelligent analysis. I take no advertising or sponsors, so my reporting isn't influenced by donations by established space or drug companies. Instead, I rely entirely on donations and subscriptions from my readers, which gives me the freedom to write what I think, unencumbered by outside influences.
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The uncertainty of science: Mice flown for almost two weeks on the last space shuttle mission in 2011 have shown evidence of the early symptoms of liver disease.
The mice spent time orbiting the Earth on the final space shuttle flight in 2011. Once they returned home, teams of scientists were allowed to share and study their internal organs.
Jonscher’s team found that spaceflight resulted in increased fat storage in the liver, comparing pair-fed mice on Earth to those on the shuttle. This was accompanied by a loss of retinol, an animal form of Vitamin A, and changes to levels of genes responsible for breaking down fats. As a result, mice showed signs of nonalcoholic fatty liver disease (NAFLD) and potential early indicators for the beginnings of fibrosis, which can be one of the more progressive consequences of NAFLD. “It generally takes a long time, months to years, to induce fibrosis in mice, even when eating an unhealthy diet,” Jonscher said. “If a mouse is showing nascent signs of fibrosis without a change in diet after 13 ½ days, what is happening to the humans?”
This result doesn’t prove that weightlessness causes liver damage. It only suggests that more research is needed, though the data from six month to year long missions suggest that the liver harm to humans is either non-existent or temporary.
Readers!
Please consider supporting my work here at Behind the Black. Your support allows me the freedom and ability to analyze objectively the ongoing renaissance in space, as well as the cultural changes -- for good or ill -- that are happening across America. Fourteen years ago I wrote that SLS and Orion were a bad ideas, a waste of money, would be years behind schedule, and better replaced by commercial private enterprise. Only now does it appear that Washington might finally recognize this reality.
In 2020 when the world panicked over COVID I wrote that the panic was unnecessary, that the virus was apparently simply a variation of the flu, that masks were not simply pointless but if worn incorrectly were a health threat, that the lockdowns were a disaster and did nothing to stop the spread of COVID. Only in the past year have some of our so-called experts in the health field have begun to recognize these facts.
Your help allows me to do this kind of intelligent analysis. I take no advertising or sponsors, so my reporting isn't influenced by donations by established space or drug companies. Instead, I rely entirely on donations and subscriptions from my readers, which gives me the freedom to write what I think, unencumbered by outside influences.
You can support me either by giving a one-time contribution or a regular subscription. There are four ways of doing so:
1. Zelle: This is the only internet method that charges no fees. All you have to do is use the Zelle link at your internet bank and give my name and email address (zimmerman at nasw dot org). What you donate is what I get.
2. Patreon: Go to my website there and pick one of five monthly subscription amounts, or by making a one-time donation.
3. A Paypal Donation or subscription:
4. Donate by check, payable to Robert Zimmerman and mailed to
Behind The Black
c/o Robert Zimmerman
P.O.Box 1262
Cortaro, AZ 85652
You can also support me by buying one of my books, as noted in the boxes interspersed throughout the webpage or shown in the menu above.
Seems NASA would have found liver damage in astronauts by now if this was an issue in humans.
I generally agree, which is why I expressed skepticism in my post. Nonetheless, there are still too many unknowns about the medical problems that weightlessness can cause, and thus any evidence of a new problem should be looked into, closely.