Does zero gravity cause intestinal issues?
The uncertainties of science: New research simulating microgravity on Earth now suggests that zero gravity might weaken the walls of the intestines.
The barrier function of the intestinal epithelium, he added, is critical for maintaining a healthy intestine; when disrupted, it can lead to increased permeability or leakiness. This, in turn, can greatly increase the risk of infections and chronic inflammatory conditions such as inflammatory bowel disease, celiac disease, Type 1 diabetes, and liver disease.
McCole’s team used a rotating wall vessel — a bioreactor that maintains cells in a controlled rotation environment that simulates near weightlessness — to examine the impact of simulated microgravity on cultured intestinal epithelial cells.
Following culture for 18 days in the vessel, the team discovered intestinal epithelial cells showed delayed formation of “tight junctions,” which are junctions that connect individual epithelial cells and are necessary for maintaining impermeability. The rotating wall vessel also produces an altered pattern of tight junction assembly that is retained up to 14 days after the intestinal epithelial cells were removed from the vessel.
This is good research, but it has not proved anything, merely indicated an area of research that needs a follow-up in space. I also wonder if there has been any evidence of this phenomenon from astronauts returning from long missions. As far as I know, intestinal issues have never been mentioned as a problem post flight.
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The uncertainties of science: New research simulating microgravity on Earth now suggests that zero gravity might weaken the walls of the intestines.
The barrier function of the intestinal epithelium, he added, is critical for maintaining a healthy intestine; when disrupted, it can lead to increased permeability or leakiness. This, in turn, can greatly increase the risk of infections and chronic inflammatory conditions such as inflammatory bowel disease, celiac disease, Type 1 diabetes, and liver disease.
McCole’s team used a rotating wall vessel — a bioreactor that maintains cells in a controlled rotation environment that simulates near weightlessness — to examine the impact of simulated microgravity on cultured intestinal epithelial cells.
Following culture for 18 days in the vessel, the team discovered intestinal epithelial cells showed delayed formation of “tight junctions,” which are junctions that connect individual epithelial cells and are necessary for maintaining impermeability. The rotating wall vessel also produces an altered pattern of tight junction assembly that is retained up to 14 days after the intestinal epithelial cells were removed from the vessel.
This is good research, but it has not proved anything, merely indicated an area of research that needs a follow-up in space. I also wonder if there has been any evidence of this phenomenon from astronauts returning from long missions. As far as I know, intestinal issues have never been mentioned as a problem post flight.
Readers!
My annual February birthday fund-raising drive for Behind the Black is now over. Thank you to everyone who donated or subscribed. While not a record-setter, the donations were more than sufficient and slightly above average.
As I have said many times before, I can’t express what it means to me to get such support, especially as no one is required to pay anything to read my work. Thank you all again!
For those readers who like my work here at Behind the Black and haven't contributed so far, please consider donating or subscribing. My analysis of space, politics, and culture, taken from the perspective of an historian, is almost always on the money and ahead of the game. For example, in 2020 I correctly predicted that the COVID panic was unnecessary, that the virus was apparently simply a variation of the flu, that masks were not simply pointless but if worn incorrectly were a health threat, that the lockdowns were a disaster and did nothing to stop the spread of COVID. Every one of those 2020 conclusions has turned out right.
Your help allows me to do this kind of intelligent analysis. I take no advertising or sponsors, so my reporting isn't influenced by donations by established space or drug companies. Instead, I rely entirely on donations and subscriptions from my readers, which gives me the freedom to write what I think, unencumbered by outside influences.
You can support me either by giving a one-time contribution or a regular subscription. There are four ways of doing so:
1. Zelle: This is the only internet method that charges no fees. All you have to do is use the Zelle link at your internet bank and give my name and email address (zimmerman at nasw dot org). What you donate is what I get.
2. Patreon: Go to my website there and pick one of five monthly subscription amounts, or by making a one-time donation.
3. A Paypal Donation or subscription:
4. Donate by check, payable to Robert Zimmerman and mailed to
Behind The Black
c/o Robert Zimmerman
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Cortaro, AZ 85652
You can also support me by buying one of my books, as noted in the boxes interspersed throughout the webpage or shown in the menu above.
Tether & spin up on the way to Mars. It would solve so many of the identified problems.
I was wondering how you could simulate not having Earth’s gravity by rotating something in Earth’s gravity field.
According to one of the linked articles, the “”Rotating Wall Vessel” is a horizontally-mounted cylinder that rotates about this horizontal axis. The cells inside thus experience a rotating gravitational vector; the net gravitational force on them over time is zero. The cells are essentially suspended in the medium they are floating in.
This sounds a bit hokey to me, as maybe the net gravitational force is zero, but the instantaneous is certainly not. Maybe I’m not getting it, but it doesn’t seem to me that this is a good simulation of real microgravity.