ISS research suggests weightlessness accelerates aging in stem cells
According to a study that flew stem cells on four separate missions to ISS ranging in length from 32 to 45 days, weightlessness appears to age stem cells significantly.
Researchers from University of California San Diego Sanford Stem Cell Institute have discovered that spaceflight accelerates the aging of human hematopoietic stem and progenitor cells (HSPCs), which are vital for blood and immune system health. In a study published in Cell Stem Cell, the team used automated artificial intelligence (AI)-driven stem cell-tracking nanobioreactor systems in four SpaceX Commercial Resupply Services missions to the International Space Station (ISS) to track stem cell changes in real time. The findings show that the cells lost some of their ability to make healthy new cells, became more prone to DNA damage and showed signs of faster aging at the ends of their chromosomes after spaceflight — all signs of accelerated aging.
Upon return to Earth the study also found the cells recovered somewhat.
You can read the peer-reviewed paper here.
In a sense, this study confirms what numerous other research has found, that weightlessness mimics the conditions of old age, and causes the same physical decline seen in the elderly. It also shows that much of that damage in weightlessness is transient, recovering upon return to Earth.
This research once again highlights the imperative need to study the impact on various levels of artificial gravity on the human body. Will producing a 10% g environment — using centrifugal force — mitigate these negative impacts? Or will we have to simulate a full 1 g environment? Or something in between?
The first option is much easier in terms of engineering. The last will be complex and take time to develop.
At the moment almost no research has been done in this area. And it needs to happen soon, if people intend to go to Mars in the near future. Such journeys, six months minimum in weightlessness, are likely to leave the passengers somewhat debilitated upon arrival, no matter how much they exercise along the way. And being debilitated is not a good condition for a pioneer trying to build a new civilization on an alien world.
According to a study that flew stem cells on four separate missions to ISS ranging in length from 32 to 45 days, weightlessness appears to age stem cells significantly.
Researchers from University of California San Diego Sanford Stem Cell Institute have discovered that spaceflight accelerates the aging of human hematopoietic stem and progenitor cells (HSPCs), which are vital for blood and immune system health. In a study published in Cell Stem Cell, the team used automated artificial intelligence (AI)-driven stem cell-tracking nanobioreactor systems in four SpaceX Commercial Resupply Services missions to the International Space Station (ISS) to track stem cell changes in real time. The findings show that the cells lost some of their ability to make healthy new cells, became more prone to DNA damage and showed signs of faster aging at the ends of their chromosomes after spaceflight — all signs of accelerated aging.
Upon return to Earth the study also found the cells recovered somewhat.
You can read the peer-reviewed paper here.
In a sense, this study confirms what numerous other research has found, that weightlessness mimics the conditions of old age, and causes the same physical decline seen in the elderly. It also shows that much of that damage in weightlessness is transient, recovering upon return to Earth.
This research once again highlights the imperative need to study the impact on various levels of artificial gravity on the human body. Will producing a 10% g environment — using centrifugal force — mitigate these negative impacts? Or will we have to simulate a full 1 g environment? Or something in between?
The first option is much easier in terms of engineering. The last will be complex and take time to develop.
At the moment almost no research has been done in this area. And it needs to happen soon, if people intend to go to Mars in the near future. Such journeys, six months minimum in weightlessness, are likely to leave the passengers somewhat debilitated upon arrival, no matter how much they exercise along the way. And being debilitated is not a good condition for a pioneer trying to build a new civilization on an alien world.