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Using fish to study bone loss in weightlessness

A Japanese experiment on ISS, comparing the development of fish in weightlessness with those on the ground, has provided` scientists more information about bone density loss in weightlessness.

Akira Kudo at Tokyo Institute of Technology, together with scientists across Japan, have shown that medaka fish reared on the International Space Station for 56 days experienced increased osteoclast activity – bone cells involved in the re-absorption of bone tissue – likely leading to a subsequent reduction of bone density. They also found several genes that were upregulated in the fish during the space mission. The team generated fish with osteoclasts that emit a fluorescent signal. They sent 24 fish into space as juveniles, and monitored their development for 56 days under microgravity. The results were compared with a fish control group kept on Earth.

Kudo and his team found that bone mineral density in the pharyngeal bone (the jaw bone at the back of the throat) and the teeth of the fish reduced significantly, with decreased calcification by day 56 compared with the control group. This thinning of bone was accompanied by an increase in the volume and activity of osteoclasts. The team conducted whole transcriptome analysis of the fish jaws, and uncovered two strongly upregulated genes (fkbp5 and ddit4), together with 15 other mitochondria-related genes whose expression was also enhanced. Reduced movement under microgravity also has an influence. The fish began to exhibit unusual behavior towards the latter stages of their stay in space, showing motionless at day 47.

What the data mostly confirms is that long-term weightlessness is a bad thing for the development of bones, and not just in humans. Whether scientists can use these results to counter these harmful effects is not clear, however.

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Conscious Choice cover

Now available in hardback and paperback as well as ebook!

 

From the press release: In this ground-breaking new history of early America, historian Robert Zimmerman not only exposes the lie behind The New York Times 1619 Project that falsely claims slavery is central to the history of the United States, he also provides profound lessons about the nature of human societies, lessons important for Americans today as well as for all future settlers on Mars and elsewhere in space.

 
Conscious Choice: The origins of slavery in America and why it matters today and for our future in outer space, is a riveting page-turning story that documents how slavery slowly became pervasive in the southern British colonies of North America, colonies founded by a people and culture that not only did not allow slavery but in every way were hostile to the practice.  
Conscious Choice does more however. In telling the tragic history of the Virginia colony and the rise of slavery there, Zimmerman lays out the proper path for creating healthy societies in places like the Moon and Mars.

 

“Zimmerman’s ground-breaking history provides every future generation the basic framework for establishing new societies on other worlds. We would be wise to heed what he says.” —Robert Zubrin, founder of founder of the Mars Society.

 

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2 comments

  • DougSpace

    We should do no more of these studies until we conduct a tether and spin-up experiment. If successful, this experiment might, to a large degree negate the innumerable studies of the negative health effects of zero-gee.

  • PeterF

    Bone loss for humans who plan to return to a 1G environment is a problem. We will have to devise a solution or a work-around to overcome it. I prefer to look at all new extraterrestrial knowledge through rose colored serendipity glasses.

    The million dollar question is:

    Can boneless fish be bred in microgravity?

    What a great source of protein for exploration expeditions as well as the inevitable asteroid miners!

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