Two mouse embryos successfully grown on ISS
Taken from figure 2 of the paper
In a paper just published, scientists reveal that in 2021 they successfully grew two mouse embryos in weightlessness on ISS, suggesting that “perhaps mammalian space reproduction is possible, although it may be somewhat affected,” as they note in the conclusion of their paper [pdf].
From the papers abstract:
The embryos cultured under microgravity conditions developed into blastocysts with normal cell numbers, ICM, trophectoderm, and gene expression profiles similar to those cultured under artificial-1 g control on the International Space Station and ground-1 g control, which clearly demonstrated that gravity had no significant effect on the blastocyst formation and initial differentiation of mammalian embryos.
The images to the right come from the paper’s second figure, and compare the blastocysts from a ground control (top), an 1g artificial sample on ISS (middle), and the weightless result (bottom).
The experiment has many uncertainties, with the low number of embryos tested the most important. Quoting the paper’s conclusion again, the possibilities of refining this experiment for better results are great:
Unfortunately, the number of blastocysts obtained from the ISS experiment was not abundant; and we have not been able to confirm the impact on offspring because we have not produced offspring from embryos developed in space. We believe that the ETC [the experiment itself] will allow blastocysts to be frozen on the ISS if a cryoprotectant is used in place of PFA [a solution of formaldehyde]. Then, the frozen blastocysts could be brought back to Earth for transfer to a female recipient, and the viability of the blastocysts could be evaluated. Moreover, we could design a device to launch frozen oocytes and spermatozoa to the ISS, where in vitro fertilization experiments could be performed in microgravity. The use of this approach would be cheaper. Furthermore, the study of mammalian reproduction in space is essential to start the space age, making it necessary to study and clarify the effect of space environment before the ISS is no longer operational.
Despite the uncertainties, these results are significant. They suggest that human reproduction in zero gravity is possible, which also suggests it will be even more possible in lower gravity environments like the Moon or Mars.
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In 2020 when the world panicked over COVID I wrote that the panic was unnecessary, that the virus was apparently simply a variation of the flu, that masks were not simply pointless but if worn incorrectly were a health threat, that the lockdowns were a disaster and did nothing to stop the spread of COVID. Only in the past year have some of our so-called experts in the health field have begun to recognize these facts.
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Taken from figure 2 of the paper
In a paper just published, scientists reveal that in 2021 they successfully grew two mouse embryos in weightlessness on ISS, suggesting that “perhaps mammalian space reproduction is possible, although it may be somewhat affected,” as they note in the conclusion of their paper [pdf].
From the papers abstract:
The embryos cultured under microgravity conditions developed into blastocysts with normal cell numbers, ICM, trophectoderm, and gene expression profiles similar to those cultured under artificial-1 g control on the International Space Station and ground-1 g control, which clearly demonstrated that gravity had no significant effect on the blastocyst formation and initial differentiation of mammalian embryos.
The images to the right come from the paper’s second figure, and compare the blastocysts from a ground control (top), an 1g artificial sample on ISS (middle), and the weightless result (bottom).
The experiment has many uncertainties, with the low number of embryos tested the most important. Quoting the paper’s conclusion again, the possibilities of refining this experiment for better results are great:
Unfortunately, the number of blastocysts obtained from the ISS experiment was not abundant; and we have not been able to confirm the impact on offspring because we have not produced offspring from embryos developed in space. We believe that the ETC [the experiment itself] will allow blastocysts to be frozen on the ISS if a cryoprotectant is used in place of PFA [a solution of formaldehyde]. Then, the frozen blastocysts could be brought back to Earth for transfer to a female recipient, and the viability of the blastocysts could be evaluated. Moreover, we could design a device to launch frozen oocytes and spermatozoa to the ISS, where in vitro fertilization experiments could be performed in microgravity. The use of this approach would be cheaper. Furthermore, the study of mammalian reproduction in space is essential to start the space age, making it necessary to study and clarify the effect of space environment before the ISS is no longer operational.
Despite the uncertainties, these results are significant. They suggest that human reproduction in zero gravity is possible, which also suggests it will be even more possible in lower gravity environments like the Moon or Mars.
Readers!
Please consider supporting my work here at Behind the Black. Your support allows me the freedom and ability to analyze objectively the ongoing renaissance in space, as well as the cultural changes -- for good or ill -- that are happening across America. Fourteen years ago I wrote that SLS and Orion were a bad ideas, a waste of money, would be years behind schedule, and better replaced by commercial private enterprise. Only now does it appear that Washington might finally recognize this reality.
In 2020 when the world panicked over COVID I wrote that the panic was unnecessary, that the virus was apparently simply a variation of the flu, that masks were not simply pointless but if worn incorrectly were a health threat, that the lockdowns were a disaster and did nothing to stop the spread of COVID. Only in the past year have some of our so-called experts in the health field have begun to recognize these facts.
Your help allows me to do this kind of intelligent analysis. I take no advertising or sponsors, so my reporting isn't influenced by donations by established space or drug companies. Instead, I rely entirely on donations and subscriptions from my readers, which gives me the freedom to write what I think, unencumbered by outside influences.
You can support me either by giving a one-time contribution or a regular subscription. There are four ways of doing so:
1. Zelle: This is the only internet method that charges no fees. All you have to do is use the Zelle link at your internet bank and give my name and email address (zimmerman at nasw dot org). What you donate is what I get.
2. Patreon: Go to my website there and pick one of five monthly subscription amounts, or by making a one-time donation.
3. A Paypal Donation or subscription:
4. Donate by check, payable to Robert Zimmerman and mailed to
Behind The Black
c/o Robert Zimmerman
P.O.Box 1262
Cortaro, AZ 85652
You can also support me by buying one of my books, as noted in the boxes interspersed throughout the webpage or shown in the menu above.
It boggles my mind that this experiment is being done nearly 70 years after we first started sending animals to orbit.
Very interesting and useful.
As one comment on the New Atlas website suggests, it could also mean to grow animals as a food source. (In case the lab-grown meat doesn’t work as intended.) It also means we’re perhaps bringing our co-evolving ecosystem with us, willingly and accidentally.
An experiment that should have been done years ago.
By now we should have a few generations of mice on the station living just fine.