Study suggests low dose radiation reduces severe knee pain
A new study suggests that exposing patients with advanced osteoarthritis (OA) to low doses of radiation reduced their pain significantly.
The trial included 114 people with primary knee OA, diagnosed by moderate damage visible on X-rays, and significant pain with walking. They were randomly assigned to one of three groups: very low-dose radiation (0.3 Gy total, spread over six sessions of 0.05 Gy), low-dose radiation (3 Gy total, spread over six sessions of 0.5 Gy), or a sham treatment that did not deliver radiation.
…Each treatment in this trial was 500 mGy, which works out to be 5,000 times the radiation dose of a chest X-ray and around 70 times the dose of a chest CT scan. However, while this sounds like a lot, the treatment delivered in the study is still considered to be low-dose. For radiotherapy cancer treatment, for example, total doses are usually 50 to 70 Gy – so a total of 3 Gy is roughly one-twentieth or less of that.
…Trial participants couldn’t take regular pain meds during the first four months, other than occasional “rescue” meds if needed. No second round of radiation was allowed. The main treatment outcome was how many participants showed significant improvement after four months, as measured by assessments of pain and function.
The 3 Gy group did significantly better than the sham group. About 70% improved vs 42% in the sham group. Over half (57%) of people in the 3 Gy group had a clinically meaningful improvement in joint pain and function scores vs about 31% in the sham group. The 0.3 Gy group didn’t show a statistically significant improvement; about 58% improved. No meaningful differences were seen in blood markers of inflammation or in the amount of pain medication people used. The treatment was deemed to be safe, with no side effects or toxicity reported.
If this result is confirmed, it suggests strongly that especially for the older population there is now a viable treatment for knee pain that avoids surgery and could be far more reliable.
On Christmas Eve 1968 three Americans became the first humans to visit another world. What they did to celebrate was unexpected and profound, and will be remembered throughout all human history. Genesis: the Story of Apollo 8, Robert Zimmerman's classic history of humanity's first journey to another world, tells that story, and it is now available as both an ebook and an audiobook, both with a foreword by Valerie Anders and a new introduction by Robert Zimmerman.
The print edition can be purchased at Amazon or from any other book seller. If you want an autographed copy the price is $60 for the hardback and $45 for the paperback, plus $8 shipping for each. Go here for purchasing details. The ebook is available everywhere for $5.99 (before discount) at amazon, or direct from my ebook publisher, ebookit. If you buy it from ebookit you don't support the big tech companies and the author gets a bigger cut much sooner.
The audiobook is also available at all these vendors, and is also free with a 30-day trial membership to Audible.
"Not simply about one mission, [Genesis] is also the history of America's quest for the moon... Zimmerman has done a masterful job of tying disparate events together into a solid account of one of America's greatest human triumphs."--San Antonio Express-News
A new study suggests that exposing patients with advanced osteoarthritis (OA) to low doses of radiation reduced their pain significantly.
The trial included 114 people with primary knee OA, diagnosed by moderate damage visible on X-rays, and significant pain with walking. They were randomly assigned to one of three groups: very low-dose radiation (0.3 Gy total, spread over six sessions of 0.05 Gy), low-dose radiation (3 Gy total, spread over six sessions of 0.5 Gy), or a sham treatment that did not deliver radiation.
…Each treatment in this trial was 500 mGy, which works out to be 5,000 times the radiation dose of a chest X-ray and around 70 times the dose of a chest CT scan. However, while this sounds like a lot, the treatment delivered in the study is still considered to be low-dose. For radiotherapy cancer treatment, for example, total doses are usually 50 to 70 Gy – so a total of 3 Gy is roughly one-twentieth or less of that.
…Trial participants couldn’t take regular pain meds during the first four months, other than occasional “rescue” meds if needed. No second round of radiation was allowed. The main treatment outcome was how many participants showed significant improvement after four months, as measured by assessments of pain and function.
The 3 Gy group did significantly better than the sham group. About 70% improved vs 42% in the sham group. Over half (57%) of people in the 3 Gy group had a clinically meaningful improvement in joint pain and function scores vs about 31% in the sham group. The 0.3 Gy group didn’t show a statistically significant improvement; about 58% improved. No meaningful differences were seen in blood markers of inflammation or in the amount of pain medication people used. The treatment was deemed to be safe, with no side effects or toxicity reported.
If this result is confirmed, it suggests strongly that especially for the older population there is now a viable treatment for knee pain that avoids surgery and could be far more reliable.
On Christmas Eve 1968 three Americans became the first humans to visit another world. What they did to celebrate was unexpected and profound, and will be remembered throughout all human history. Genesis: the Story of Apollo 8, Robert Zimmerman's classic history of humanity's first journey to another world, tells that story, and it is now available as both an ebook and an audiobook, both with a foreword by Valerie Anders and a new introduction by Robert Zimmerman.
The print edition can be purchased at Amazon or from any other book seller. If you want an autographed copy the price is $60 for the hardback and $45 for the paperback, plus $8 shipping for each. Go here for purchasing details. The ebook is available everywhere for $5.99 (before discount) at amazon, or direct from my ebook publisher, ebookit. If you buy it from ebookit you don't support the big tech companies and the author gets a bigger cut much sooner.
The audiobook is also available at all these vendors, and is also free with a 30-day trial membership to Audible.
"Not simply about one mission, [Genesis] is also the history of America's quest for the moon... Zimmerman has done a masterful job of tying disparate events together into a solid account of one of America's greatest human triumphs."--San Antonio Express-News
I will be forwarding this article to my friend who I just had lunch with (We both had beef / lamb Gyros, deeeelicious! :)
He has pretty bad pain in both knees due to arthritic.
Much appreciated.
Very interesting!
There is definitely something to this. It’s a shame we weren’t studying this type of Stuff for the past 50 years, instead of hating on all things nuclear.
tangentially on a lighter Note:
I happen to own a “Radium Ore Revigator,” stoneware water-cooler. (2 gallon) The interior used uranium-oxide in a porous glaze, and the water then absorbs the “radon and radium.” HAR– It does have a US Patent for the method of incorporating the “radio-active materials,” but otherwise makes no health claims.
The Advertising claims however are wonderfully over-the-top! (This is 1926)
https://orau.org/health-physics-museum/collection/radioactive-quack-cures/jars/revigator-1924-1926.html
(And of course I have the radioactive Fiesta dinnerware collection.)
Not surprised, I have always heard of this. This will be big business for Radium Hot Springs near Banff.
Wayne:
Leave it up to you to report about such a device, and actually possess one!
Very interesting.