Tag: medical research

Part 1: The ugly corrupt lie of the experimental COVID jab

2:16 pm

Joe Biden: dictator
Joe Biden: claiming the power to tell us what medicines we must take

On September 9, 2021, President Joe Biden announced harsh mandates nationwide that forced millions to get COVID shots. You had no choice. If you refused, you would be fired from your job and made a non-person, forbidden in all ways from participating normally in society.

“We’ve been patient, but our patience is wearing thin,” Biden said, making a direct appeal to the 80 million people who he said were still unvaccinated. “Your refusal has cost all of us.”

…”It’s simple [said an official]: If you want to work for the federal government, you must be vaccinated. If you want to do business with the government, you must vaccinate your workforce.”

Those mandates — unreasonably based on very uncertain knowledge at the time — have now been found to have killed thousands of people who did not need to die.

And worst of all, the people imposing those mandates were lying, and knew they were lying.

Killing young adults

For a large majority of the population that either voluntarily chose to get the COVID jab or were forced to submit under duress, the shots and boosters at this point appear to have been harmless. Most people have exhibited no negative symptoms once jabbed, and have so far been able to go on with their lives as if nothing had changed.

The problem is that for many, that jab was a death sentence, with the executioner often arriving unexpectedly but quickly, and completely unnecessarily.
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Study: Russian astronauts on ISS have better techniques for protecting the brain

9:12 am

According to a study comparing the changes in the brain experienced during long term missions on ISS, it appears that the Russians have developed better protocols for preparing themselves for return to Earth that prevents the enlargement in one part of the brain seen in American astronauts.

From the link:

The study focused on 24 Americans, 13 Russians, and a small, unspecified number of astronauts from the ESA. The researchers collected MRI scans of the astronauts’ brains before and after they spent six months on the ISS (only 256 individuals have visited the space station).

After being in space, all the space travelers exhibited similar brain changes: cerebrospinal fluid buildup and reduced space between the brain and the surrounding membrane at the top of the head. The Americans, however, also had more enlargement in the regions of the brain that serve as a cleaning system during sleep, e.g. the perivascular space (PVS).

…The Russian astronauts did not exhibit enlarged PVS, suggesting there might be differences in protocol that are neuro-protective.

From the paper itself:

[Russian C]osmonauts undergo six lower body negative pressure (LBNP) sessions starting two weeks prior to landing, while NASA and ESA astronauts do not typically do it. LBNP induces caudal displacement of fluids from the upper body by placing the legs and pelvis in a semiairtight chamber with negative pressure.

An advanced resistive exercise device (ARED) is regularly used by space flyers to perform free weight exercises on the ISS, but the load and frequency of use are lower for [Russian] cosmonauts compared with NASA and ESA astronauts. Lifting heavy loads during resistive exercise is often accompanied by a brief Valsalva maneuver, inducing increased ICP and decreased cerebral blood flow and cerebrovascular transmural pressure, which can result in PVS fluid accumulation. Although the effects of LBNP and ARED on the brain during spaceflight are unknown, they could partly explain the different WM-PVS changes detected in astronauts and cosmonauts. We cannot exclude that other factors (e.g., diet) might play a role in this difference. Further studies are required to confirm these hypotheses.

Apparently two protocols are different that seem to help the Russians. First, the LBNP, developed by the Russians on their earlier space stations, is essentially a pair of pants that sucks fluids down to the legs, simulating the situation normally found on Earth, and thus reduces the fluids in the upper body sooner than landing. Second, doing exercises simulating lower weight loads apparently helps the Russians as well.

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Study: U.S. mortality rates suggest background radiation actually beneficial

9:10 am

The uncertainty of science: According to a new study by researchers at Ben-Gurion University in Israel of mortality rates across the entire United States, people that live in regions of higher background radiation have lifespans on average 2.5 years longer.

Background radiation is an ionizing radiation that exists in the environment because of natural sources. In their study, BGU researchers show that life expectancy is approximately 2.5 years longer among people living in areas with a relatively high vs. low background radiation. Background radiation includes radiation emanating from space, and radiation from terrestrial sources. Since the 1960s, there has been a linear no-threshold hypothesis guiding policy that any radiation level carries some risk. Hundreds of billions of dollars are spent around the world to reduce radiation levels as much as possible.

…According to BGU Professors Vadim Fraifeld and Marina Wolfson, along with Dr. Elroei David of the Nuclear Research Center Negev, lower levels of several types of cancers were found when the radiation levels were on the higher end of the spectrum rather than on the lower end. Among both men and women, there was a significant decrease in lung, pancreatic, colon and rectal cancers. Among men, there were additional decreases in brain and bladder cancers. There was no decrease in cervix, breast or prostate cancers or leukemia.

Their data “covered the entire US population of the 3139 US counties, encompassing over 320 million people,” according to their paper’s abstract.

Up until now the assumption has been that any radiation is bad, based not on research but on assumptions gained by the negative consequence of exposure to high radiation. There has been no good data on the consequences of low level background radiation, because it is so hard to gather. The time frames are long and the numbers small, all of which causes the impact of background radiation to be overwhelmed by other factors. This study’s statistical use of the entire U.S. population is an attempt to overcome these obstacles.

This study is statistical, which means it found a correlation between higher radiation and longer lifespans. Correlation however does not prove causation. The study found no direct evidence that humans health benefits from background radiation. We should therefore take these results with a large grain of salt.

At the same time, their extremely large database is quite telling, and adds some weight to their conclusion.

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New changes to the brain found from long space missions

8:38 am

Scientists have discovered a “significant increase” in the brain’s white matter that occurs after astronauts have completed long missions in weightlessness.

The team conducted brain MRIs of 11 astronauts before they traveled to the ISS, and then again one day after they returned. Scans were then performed at several interval across the following year. “What we identified that no one has really identified before is that there is a significant increase of volume in the brain’s white matter from preflight to postflight,” Kramer says. “White matter expansion in fact is responsible for the largest increase in combined brain and cerebrospinal fluid volumes postflight.”

These changes remained visible one year after spaceflight, which the researchers say indicates they could be permanent alterations. Past research has suggested that changes in the volume of cerebrospinal fluid (CSF) specifically could be a key driver of Visual Impairment Intracranial Pressure in astronauts. The authors of the new study also observed an increase in the velocity of CSF through the cerebral aqueduct, along with deformation of the pituitary gland, which they believe is related to higher intracranial pressure in microgravity.

The uncertainties for this work remain very large. For one thing, the sample (11 astronauts) is very small. For another, the permanence of this change is only suggested and remains unproven.

Nonetheless, this research adds to the growing body of research that suggests that long term weightlessness is generally not good for the human body. It also reinforces the desperate need for research into the effects of even a small amount of artificial gravity. To most efficiently design spacecraft that provide some form of centrifugal force as artificial gravity, we need to find out the minimum required. It could be providing only 10% or 30% Earth gravity could be sufficient. Or not. We just don’t know.

The engineering challenges however go up significantly the more gravity you need to create. For future interplanetary travel this information is critical.

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Study says space radiation less of a risk

9:05 am

A newly released study now claims that, based on a long term review of astronauts who have spent a considerable time in space, it appears that space radiation does not cause an increase in cancer later in life.

The new study analyzed information from 418 space travelers, including 301 NASA astronauts who had traveled to space at least once since 1959, and 117 Russian or Soviet cosmonauts who had traveled to space at least once since 1961. These participants were followed for about 25 years, on average.

During this time, 89 of the participants died. Among the 53 NASA astronauts who died, 30% died from cancer and 15% from heart disease; while among the 36 Russian or Soviet cosmonauts who died, 50% died from heart disease and 28% from cancer.

The researchers used a special statistical technique to determine whether deaths from cancer and heart disease likely had a common cause — in this case, the common cause would be space radiation. But their results did not point to a common cause of death. “If ionizing radiation is impacting the risk of death due to cancer and cardiovascular disease, the effect is not dramatic,” the authors wrote in their study, published July 4 in the journal Scientific Reports.

This story first appeared about two weeks ago, but I didn’t think it significant, and still don’t. The sample is just not large enough to draw any solid conclusions. Moreover, this is exposure in low Earth orbit, not on interplanetary missions where the radiation risk is higher. It would be a big mistake for future space engineering to accept these findings blindly.

Still, news reports keep popping up about it, and I decided I should at least note it here on Behind the Black.

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Faking gravity in space with a spinning table

2:38 pm

Researchers at the University of Colorado in Boulder are experimenting with the use of a rotating table to give space-farers short doses of artificial gravity in order to mitigate the negative consequences of weightlessness.

In a series of recent studies, the pair and their colleagues set out to investigate whether queasiness is really the price of admission for artificial gravity. In other words, could astronauts train their bodies to tolerate the strain that comes from being spun around in circles like hamsters in a wheel?

The team began by recruiting a group of volunteers and tested them on the centrifuge across 10 sessions.

But unlike most earlier studies, the CU Boulder researchers took things slow. They first spun their subjects at just one rotation per minute, and only increased the speed once each recruit was no longer experiencing the cross-coupled illusion. “I present at a conference and everyone says, ‘she’s the one who spins people and makes them sick,'” Bretl said. “But we try to avoid instances of motion sickness because the whole point of our research is to make it tolerable.”

The personalized approach worked. By the end of 10th session, the study subjects were all spinning comfortably, without feeling any illusion, at an average speed of about 17 rotations per minute. That’s much faster than any previous research had been able to achieve.

The idea is that you could install this rotating table on a interplanetary ship, and have its occupants periodically spend time on it to get their daily dose of gravity. This way you would not have to build a giant spinning spaceship.

The research has potential. The one question that remains unanswered and is probably central to this concept is how little gravity is needed to avoid the problems of weightlessness. Right now, we do not know. It could be for example that 30 minutes at 1/10 g could do the job. Or maybe 1 g for 2 hours. If the former the engineering challenges become minor. If the latter the problems are more difficult.

I am aware of only one centrifuge experiment ever done in weightlessness, on a Russian space station. They rotated a plant at a very tiny percentage of g’s and found it might help plants prosper in space. The data point however is too small, with no followup. This is the kind of research that should be going on on ISS, and is not.

Hat tip Marcus A.

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Possible cure for AIDS?

9:17 pm

In the past week researchers have revealed that two different patients have apparently had the AIDS HIV virus eliminated from their bodies.

The virus infects cells of the immune system, which are made in the bone marrow. A man known as the “Berlin patient” was the first person to become HIV-free after cancer treatment, back in 2007. To treat his leukaemia – a cancer of the immune system – he was given a treatment that involved killing nearly all his immune cells with radiotherapy or drugs, and then replacing them with cells from a donor. This donor was naturally resistant to HIV, thanks to a rare but natural mutation in a gene called CCR5.

Since then, no one else had had HIV eliminated from their body in the same way, until a second case was announced on Monday. This person, known as the London patient, was given bone marrow from a donor with the CCR5 mutation as a treatment for Hodgkin’s lymphoma, another immune cell cancer. He was advised to stop taking the antiviral drugs that keep the virus in check about a year afterwards. Eighteen months later, the virus hasn’t returned.

A possible third case was then announced today, at the Conference on Retroviruses and Opportunistic Infections in Seattle.

The more than dozen year gap between the first cure and the two this week is partly because it takes so long to perform the treatment and then confirm the virus is gone. Moreover, this treatment can only be given to a limited number of patients, because of the risks involved.

Nonetheless, if this cure is proven viable, it will be a great triumph for modern science.

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How NIMH policy effects research

8:24 am

The uncertainty of science: A policy change in how the National Institute of Mental Health (NIMH) awards grants during the Obama administration has had a profound influence on the research of mental-health in the United States.

An analysis by Nature suggests that the number of clinical trials funded by the NIMH dropped by 45% between 2009 and 2015. This coincides with the agency’s launch, in 2011, of the Research Domain Criteria (RDoC) — a framework for research on the mechanisms of mental illness. The NIMH’s roll-out of RDoC included asking researchers to focus more on the biological bases of behaviour — such as brain circuitry and genetics — than on the broader symptoms that clinicians typically use to define and classify mental illness.

The NIMH’s embrace of fundamental research has infuriated many clinical researchers, who see it as an attempt to invalidate their methods — and say that there is scant evidence to support the idea that using RDoC will lead to greater insight or better treatments for mental illness. Many of these researchers also note that NIMH funding for clinical trials has declined steadily over the past decade, adding to the perception that the agency now favours research that uses the RDoC framework.

Read the article. I have no idea if the change in NIMH policy is a good or bad thing. What disturbs me however is the federal government’s overall top-down control over mental-health research. Rather than obtain funding from many different sources — which would allow for the greatest flexibility and the most creativity — this research field appears to depend almost entirely on NIMH grants. Thus, the particular preferences of that agency dictates the nature of the research, whether or not its preferences are right.

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A centrifuge costing 20 cents based on a toy

9:22 am

Scientists at Stanford have developed a centrifuge costing 20 cents to make, based on a child’s toy, that can be used in the field to separate blood samples.

According to Stanford, Prakash and post-doctoral fellow Saad Bhamla came up with the “paperfuge” while looking at toys like tops and yo-yos for inspiration. Noticing how the disc of a whirligig spins when the cords on either side are pulled, they decided to make a slow motion video of one, only to discover that it rotated at 10,000 to 15,000 RPM.

The pair started developing prototypes using a blood capillary tube mounted on a paper disc, but they went beyond simple tinkering as they recruited three undergraduate engineering students from MIT and Stanford to create mathematical models of how the whirligig could change a pulling motion into a rotary motion. Looking at variables like disc size, string elasticity, and pulling force, they combined this with equations from the physics of supercoiling DNA to gain a better understanding of the whirligig’s mechanism.

The result was a centrifuge made of 20 cents of paper, twine, and plastic that could spin at 125,000 RPM, generate 3,000 G’s, and process samples in 1.5 minutes.

I have embedded a video explaining the paperfuge below the fold. I wonder if a variation of this on ISS could do low gravity experiments.
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Vision problems from weightlessness

6:03 pm

This article provides an excellent review of the vision problems caused by long term exposure to weightlessness, including the efforts to study the problem on Earth.

Bottom line:

Before a human trip to Mars — a journey of six-to-nine months that NASA says it wants to achieve by the 2030s — researchers agree that VIIP [the name given to this problem] must be understood much better. VIIP could be the first sign of greater dangers to the human body from microgravity. “We’re seeing the visual and neural, ophthalmic manifestations of it,” Barratt said. “I’m fairly certain this is a bit more global than that.”

Richard Williams, the chief health and medical officer at NASA, agrees that what we do not know about VIIP still poses the biggest threat. Ironically, one of the only ways to get more knowledge is spend more time in microgravity. “The longer we stay in space, the more we’re going to learn,” Williams said.

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Avoiding the period in space

9:37 am

New research has outlined the techniques available to female astronauts to prevent menstruation in space.

Rather than researching the consequences of women having a period in space, the researchers are recommending that women avoid them completely, something that appears to have been the policy of NASA on ISS. This is a big mistake. The whole point of having a space station is to find out the consequences to the human body imposed by weightlessness. Future space explorers will need to reproduce. We need to know now if that will be possible.

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Good HDL cholesterol might not be so good

8:55 am

The uncertainty of science: New research now suggests an explanation for why in some cases having a high level of the supposedly good HDL cholesterol is not a good thing.

They think it is genetic, and that some people are missing the genes that help the HDL work to clean cholesterol out of the body. It is important however to recognize the uncertainties here. They still do not understand very well how this all works.

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New engineering gives a man paralyzed from the waist down the ability to walk again.

9:45 am

Using a new exoskeleton design combined with non-invasive spinal simulation engineers have made it possible for a man paralyzed from the waist down to walk again.

Leveraging on research where the UCLA team recently used the same non-invasive technique to enable five completely paralyzed men to move their legs, the new work has allowed the latest subject, Mark Pollock, to regain some voluntary movement – even up to two weeks after training with the external electrical stimulation had ended.

Pollock, who had been totally paralyzed from the waist down for four years prior to this study, was given five days of training in the robot exoskeleton, and a further two weeks muscle training with the external stimulation unit. The stimulated and voluntary leg movements have not only shown that regaining mobility through this technique is possible, but that the training itself provides a range of health benefits in itself, especially in enhanced cardiovascular function and improved muscle tone.

The new system has been created as an amalgam of a battery-driven bionic exoskeleton that allows users’ leg movements to propel the unit in a step-by-step way, and a non-invasive external stimulator to trigger nerve signals to create the leg movements. In this way, Pollock made significant progress after being given just a few weeks physical training without spinal stimulation and then five days of spinal stimulation exercise an hour a day over a week-long period. “In the last few weeks of the trial, my heart rate hit 138 beats per minute,” said Pollock. “This is an aerobic training zone, a rate I haven’t even come close to since being paralyzed while walking in the robot alone, without these interventions. That was a very exciting, emotional moment for me, having spent my whole adult life before breaking my back as an athlete.”

His ability to walk is not achieved easily, and without extensive help and preparation fades. However, the results here are very hopeful that future developments will make it possible for paraplegics to once again walk.

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Requiring scientists to document their methods caused positive results in medical trials to plunge

9:35 am

The uncertainty of science: The requirement that medical researchers register in detail the methods they intend to use in their clinical trials, both to record their data as well as document their outcomes, caused a significant drop in trials producing positive results.

A 1997 US law mandated the registry’s creation, requiring researchers from 2000 to record their trial methods and outcome measures before collecting data. The study found that in a sample of 55 large trials testing heart-disease treatments, 57% of those published before 2000 reported positive effects from the treatments. But that figure plunged to just 8% in studies that were conducted after 2000. Study author Veronica Irvin, a health scientist at Oregon State University in Corvallis, says this suggests that registering clinical studies is leading to more rigorous research. Writing on his NeuroLogica Blog, neurologist Steven Novella of Yale University in New Haven, Connecticut, called the study “encouraging” but also “a bit frightening” because it casts doubt on previous positive results.

In other words, before they were required to document their methods, research into new drugs or treatments would prove the success of those drugs or treatment more than half the time. Once they had to document their research methods, however, the drugs or treatments being tested almost never worked.

The article also reveals a failure of the medical research community to confirm their earlier positive results:

Following up on these positive-result studies would be interesting, says Brian Nosek, a psychologist at the University of Virginia in Charlottesville and the executive director of the Center for Open Science, who shared the study results on Twitter in a post that has been retweeted nearly 600 times. He said in an interview: “Have they all held up in subsequent research, or are they showing signs of low reproducibility?”

Well duh! It appears the medical research field has forgotten this basic tenet of science: A result has to be proven by a second independent study before you can take it seriously. Instead, they would do one study, get the results they wanted, and then declare success.

The lack of success once others could see their methods suggests strongly that much of the earlier research was simply junk, not to be taken seriously.

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NSF to help fund the development of implantable antennas

1:47 pm

What could possibly go wrong? The National Science Foundation (NSF) is providing funding for the development of an implantable antenna for health care, including the possibility for “long-term patient monitoring.”

The project is being financed in collaboration with the National Research Foundation of Korea to create a high frequency antenna that can be permanently implanted under a person’s skin. “Antennas operating near or inside the human body are important for a number of applications, including healthcare,” a grant for the project said. “Implantable medical devices such as cardiac pacemakers and retinal implants are a growing feature of modern healthcare, and implantable antennas for these devices are necessary to monitor battery level and device health, to upload and download data used in patient monitoring, and more.”

The grant said that an implantable device could be used for “long-term patient monitoring” and “biometric tracking,” or using technology to verify a person’s identity.

Without any doubt there are many very useful applications for such an implantable device. Monitoring battery life on pacemakers is an obvious one. There will be a problem, however, if anyone but the patient can do the monitoring. I can see too many possible misuses occurring should it be in anyone else’s hands. At a minimum, there are big privacy concerns.

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Billion-dollar-plus NASA medical research contract under dispute

11:24 pm

A bidding dispute has forced NASA to again put up for bid a $1.5 billion contract for space medicine.

The dispute has to do with two dueling contractors, Wyle and SAIC, both of whom want the big bucks.

After Wyle won the Human Health and Performance contract in March 2013, SAIC filed a protest with the GAO, ultimately prompting NASA to reopen the competition.

When NASA reawarded the contract in August 2013, it chose SAIC. The following month, the McLean, Virginia-based firm — which had announced plans the previous summer to split into two companies — rebranded itself as Leidos and spun off its $4 billion government information technology and technical services unit as a publicly traded firm that kept the name SAIC and was slated to get the Human Health and Performance contract.

But Wyle filed its own protest with GAO in September 2013, arguing that NASA should discount SAIC’s lower bid — at $975 million, nearly 10 percent lower than Wyle’s — because it was submitted when the unit was still part of a much larger company with deeper pockets. This time, the GAO sided with Wyle.

The article says practically nothing about what all this money buys me, the taxpayer. And it is an awful lot of money. Is it for medical research on ISS? Is it for monitoring the health of the astronauts? Is it for biological research? What is it for exactly? I honestly can’t imagine how this kind of research or medical monitoring on ISS can cost this much. My skeptical nature has me wondering if this contract might instead be a bit inflated, much like SLS and Orion, in order to funnel pork to congressional districts to employ as many voters as possible.

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Ebola patient arrives in U.S.

12:11 am

Doctors in charge of the specialized isolation unit for treating dangerous infectious diseases are confident that they will be able to treat the infected patients safely without the disease escaping.

I have complete confidence that a well run facility like this, with modern technology, could keep the disease isolated. The key words, however, are “well run.” I pray that this description still applies to Emory University Hospital.

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A new ligament has just been discovered in the human knee.

10:44 am

A new ligament has just been discovered in the human knee.

[T]he Belgian doctors are the first to identify the previously unknown ligament after a broad cadaver study using macroscopic dissection techniques. Their research shows that the ligament, which was given the name anterolateral ligament (ALL), is present in 97 per cent of all human knees.

This only illustrates once again that as much as we think we know, there is always something new to discover.

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The pork of Obamacare

3:00 pm

The Patient Centered Outcomes Research Institute (PCORI), created by Obamacare, announced its first round of grants today, part of a funding program of fifty “pilot projects” totaling $30 million.

It didn’t take much research for me to conclude that, while some of this work might be useful, most of it sounds like bureaucratic claptrap. For example, consider the description Nature gives for these three grants:
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