Tag: medicine

Researchers discover an anti-aging drug that extends the lives of rats 25%

9:49 am

Researchers have discovered that by blocking the increase of a certain protein within the body, they can not only extend the lives of rats by about 25%, the rats overall health in old age was improved significantly.

You can read the original paper here and the press release from the researchers here. From that press release:

After establishing IL11’s role in aging, the team demonstrated that by applying this anti-IL11 therapy in the same preclinical model, metabolism was improved. The mice shifted from generating white fat to beneficial brown fat. Brown fat breaks down blood sugar and fat molecules to help maintain body temperature and burn calories. The researchers also observed improved muscle function and overall better health in their study, as well as an increased lifespan by up to 5 per cent in both sexes.

Unlike other drugs known to inhibit specific pathways involved in aging, such as metformin and rapamycin, anti-IL11 therapy blocks multiple major signaling mechanisms that become dysfunctional with age, offering protection against cardio-metabolic diseases, age-related loss of muscle mass and strength as well as frailty. In addition to these externally observable changes, anti-IL11 therapy also reduced the rate of telomere shortening and preserved mitochondria’s health and ability to generate energy.

According the paper, this drug is now in early-stage clinical trials for fibrotic lung disease, but its benefits — as seen in these rat experiments — could turn out to be far greater, across the board.

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Two-thirds of all approved cancer drugs do nothing for patients

4:26 pm

A long term study in Sweden of 22 cancer drugs that its government had approved for rapid use before being tested fully has found that two-thirds provided absolute no benefit to patients.

The Gothenburg team examined 22 cancer drugs approved for reimbursement in Sweden over the last 10 years, examining studies that tested their ability to improve quality of life or lengthen lifespans. On average, these reports examined the drugs for 6.6 years.

Results revealed only seven of the 22 drugs had at least one study which showed a clear benefit for cancer patients. Randomized controlled trials on the other 15 failed to show any tangible benefits for people with cancer. Only one drug in the study showed an ability to both improve the quality of life and extend lifespans for patients.

“We have shown that the majority of the drugs launched with limited evidence still lack clear evidence of how they actually affect survival and quality of life in patients,” says Gabriella Chauca Strand, a doctoral student at Sahlgrenska Academy at the University of Gothenburg and the lead author of the study, in a university release.

This sentence from the university’s press release was even more striking:

Only one of the drugs had scientific evidence of both increased life expectancy and improved quality of life for its indication.

Essentially, 95% of these approved drugs were failures. Most did nothing and were worthless, despite the Swedish government paying huge amounts of money buying them. A few either improved the quality of life (but failed to keep the patient alive) or kept the patient alive longer (but made their lives miserable).

Does this sound familiar? Doesn’t make you wonder about the drug approval process in the U.S., especially after the disaster of the emergency approval of the COVID shots that we know now not only failed to prevent infection, were actually very harmful to many.

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Study: Long periods of weightlessness caused changes in the brain

9:55 am

Scientists studying the brains of 30 astronauts who spent from two weeks to one year on ISS have found that the longer a person stayed in weightlessness the greater the changes caused in the brain, and the longer it takes to recover.

Their findings, reported today in Scientific Reports, reveal that the brain’s ventricles expand significantly in those who completed longer missions of at least six months, and that less than three years may not provide enough time for the ventricles to fully recover.

Ventricles are cavities in the brain filled with cerebrospinal fluid, which provides protection, nourishment and waste removal to the brain. Mechanisms in the human body effectively distribute fluids throughout the body, but in the absence of gravity, the fluid shifts upward, pushing the brain higher within the skull and causing the ventricles to expand.

“We found that the more time people spent in space, the larger their ventricles became,” said Rachael Seidler, a professor of applied physiology and kinesiology at the University of Florida and an author of the study. “Many astronauts travel to space more than one time, and our study shows it takes about three years between flights for the ventricles to fully recover.”

You can read the paper here. The expansion of ventricles is a normal process due to aging, but I could not find any description in the paper noting its impact, for good or ill. Long periods of weightlessness brings it about quickly, but only temporarily.

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Does zero gravity cause intestinal issues?

9:23 am

The uncertainties of science: New research simulating microgravity on Earth now suggests that zero gravity might weaken the walls of the intestines.

The barrier function of the intestinal epithelium, he added, is critical for maintaining a healthy intestine; when disrupted, it can lead to increased permeability or leakiness. This, in turn, can greatly increase the risk of infections and chronic inflammatory conditions such as inflammatory bowel disease, celiac disease, Type 1 diabetes, and liver disease.

McCole’s team used a rotating wall vessel — a bioreactor that maintains cells in a controlled rotation environment that simulates near weightlessness — to examine the impact of simulated microgravity on cultured intestinal epithelial cells.

Following culture for 18 days in the vessel, the team discovered intestinal epithelial cells showed delayed formation of “tight junctions,” which are junctions that connect individual epithelial cells and are necessary for maintaining impermeability. The rotating wall vessel also produces an altered pattern of tight junction assembly that is retained up to 14 days after the intestinal epithelial cells were removed from the vessel.

This is good research, but it has not proved anything, merely indicated an area of research that needs a follow-up in space. I also wonder if there has been any evidence of this phenomenon from astronauts returning from long missions. As far as I know, intestinal issues have never been mentioned as a problem post flight.

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Nearly 400 medical procedures found to be ineffective

3:32 pm

The uncertainty of science: A new review of the science literature has found almost 400 studies showing the ineffectiveness of the medical procedure or device they were studying.

The findings are based on more than 15 years of randomised controlled trials, a type of research that aims to reduce bias when testing new treatments. Across 3,000 articles in three leading medical journals from the UK and the US, the authors found 396 reversals.

While these were found in every medical discipline, cardiovascular disease was by far the most commonly represented category, at 20 percent; it was followed by preventative medicine and critical care. Taken together, it appears that medication was the most common reversal at 33 percent; procedures came in second at 20 percent, and vitamins and supplements came in third at 13 percent.

A reversal means that the study found the procedure, device, or medicine to be ineffective.

If you have medical issues it is worth reviewing the research itself. You might find that some of the medical treatment you are getting is irrelevant, and could be discontinued.

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Possible cure for AIDS?

9:17 pm

In the past week researchers have revealed that two different patients have apparently had the AIDS HIV virus eliminated from their bodies.

The virus infects cells of the immune system, which are made in the bone marrow. A man known as the “Berlin patient” was the first person to become HIV-free after cancer treatment, back in 2007. To treat his leukaemia – a cancer of the immune system – he was given a treatment that involved killing nearly all his immune cells with radiotherapy or drugs, and then replacing them with cells from a donor. This donor was naturally resistant to HIV, thanks to a rare but natural mutation in a gene called CCR5.

Since then, no one else had had HIV eliminated from their body in the same way, until a second case was announced on Monday. This person, known as the London patient, was given bone marrow from a donor with the CCR5 mutation as a treatment for Hodgkin’s lymphoma, another immune cell cancer. He was advised to stop taking the antiviral drugs that keep the virus in check about a year afterwards. Eighteen months later, the virus hasn’t returned.

A possible third case was then announced today, at the Conference on Retroviruses and Opportunistic Infections in Seattle.

The more than dozen year gap between the first cure and the two this week is partly because it takes so long to perform the treatment and then confirm the virus is gone. Moreover, this treatment can only be given to a limited number of patients, because of the risks involved.

Nonetheless, if this cure is proven viable, it will be a great triumph for modern science.

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A simple and inexpensive skin cancer detector wins award

10:10 am

A simple and inexpensive skin cancer detector has won the $40,000 2017 James Dyson award.

Designed by a team from McMaster University in Canada, the sKan can make more accurate diagnoses quickly and reasonably cheaply. It’s based around the fact that cancer cells have a faster metabolic rate than healthy cells, meaning they release more heat. To check if a patch of skin has the beginnings of a melanoma, the suspected area is first cooled with an ice pack before the sKan device is placed against the skin.

Using an array of temperature sensors called thermistors, the sKan will then monitor the area as the skin warms back up. If there’s a melanoma present, it will warm up faster than the surrounding skin, revealing itself on a heat map and temperature difference time plot created through a connected computer program.

Once this device is in the hands of dermatologists, they will be able to very quickly diagnose whether a skin mole or freckle is dangerous or not.

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New engineering gives a man paralyzed from the waist down the ability to walk again.

9:45 am

Using a new exoskeleton design combined with non-invasive spinal simulation engineers have made it possible for a man paralyzed from the waist down to walk again.

Leveraging on research where the UCLA team recently used the same non-invasive technique to enable five completely paralyzed men to move their legs, the new work has allowed the latest subject, Mark Pollock, to regain some voluntary movement – even up to two weeks after training with the external electrical stimulation had ended.

Pollock, who had been totally paralyzed from the waist down for four years prior to this study, was given five days of training in the robot exoskeleton, and a further two weeks muscle training with the external stimulation unit. The stimulated and voluntary leg movements have not only shown that regaining mobility through this technique is possible, but that the training itself provides a range of health benefits in itself, especially in enhanced cardiovascular function and improved muscle tone.

The new system has been created as an amalgam of a battery-driven bionic exoskeleton that allows users’ leg movements to propel the unit in a step-by-step way, and a non-invasive external stimulator to trigger nerve signals to create the leg movements. In this way, Pollock made significant progress after being given just a few weeks physical training without spinal stimulation and then five days of spinal stimulation exercise an hour a day over a week-long period. “In the last few weeks of the trial, my heart rate hit 138 beats per minute,” said Pollock. “This is an aerobic training zone, a rate I haven’t even come close to since being paralyzed while walking in the robot alone, without these interventions. That was a very exciting, emotional moment for me, having spent my whole adult life before breaking my back as an athlete.”

His ability to walk is not achieved easily, and without extensive help and preparation fades. However, the results here are very hopeful that future developments will make it possible for paraplegics to once again walk.

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NSF to help fund the development of implantable antennas

1:47 pm

What could possibly go wrong? The National Science Foundation (NSF) is providing funding for the development of an implantable antenna for health care, including the possibility for “long-term patient monitoring.”

The project is being financed in collaboration with the National Research Foundation of Korea to create a high frequency antenna that can be permanently implanted under a person’s skin. “Antennas operating near or inside the human body are important for a number of applications, including healthcare,” a grant for the project said. “Implantable medical devices such as cardiac pacemakers and retinal implants are a growing feature of modern healthcare, and implantable antennas for these devices are necessary to monitor battery level and device health, to upload and download data used in patient monitoring, and more.”

The grant said that an implantable device could be used for “long-term patient monitoring” and “biometric tracking,” or using technology to verify a person’s identity.

Without any doubt there are many very useful applications for such an implantable device. Monitoring battery life on pacemakers is an obvious one. There will be a problem, however, if anyone but the patient can do the monitoring. I can see too many possible misuses occurring should it be in anyone else’s hands. At a minimum, there are big privacy concerns.

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Ebola patient arrives in U.S.

12:11 am

Doctors in charge of the specialized isolation unit for treating dangerous infectious diseases are confident that they will be able to treat the infected patients safely without the disease escaping.

I have complete confidence that a well run facility like this, with modern technology, could keep the disease isolated. The key words, however, are “well run.” I pray that this description still applies to Emory University Hospital.

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Better medicine through engineering

3:26 pm

For me, the last eight months have been very interesting when it comes to medical treatment. I have had my left hand rebuilt to eliminate chronic pain, I had my heart inspected to make sure it was working properly, and this week I had the retina in my right eye re-attached using some very clever engineering.

For once, this essay will not be about the politics of medicine and the disaster of Obamacare, which is still ongoing. Instead, I will outline how freedom and human creativity has now made possible a whole range of modern medical techniques that are either improving the quality of life for patients or literally saving their lives.
» Read more

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Scientists are considering revising the guidelines for heart risk as determined by your cholesterol levels.

2:36 pm

The uncertainty of science: Scientists are considering revising the guidelines for heart risk as determined by your cholesterol levels.

The ATP IV committee has pledged to hew strictly to the science and to focus on data from randomized clinical trials, says committee chairman Neil Stone, a cardiologist at Northwestern University School of Medicine in Chicago. If so, Krumholz argues, LDL [cholesterol] targets will be cast aside because they have never been explicitly tested. Clinical trials have shown repeatedly that statins reduce the risk of heart attack and stroke, but lowering LDL with other medications does not work as well. The benefits of statins may reflect their other effects on the body, including fighting inflammation, another risk factor for heart disease. [emphasis mine]

In other words, the assumption that’s been pushed for more than a decade that lowering your cholesterol will lower your risk of heart attack has never been tested or proven. If this isn’t science by myth I don’t know what is.

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Astronaut Sunita Williams completed first simulated triathlon in space this past weekend on ISS.

9:10 am

Astronaut Sunita Williams completed the first simulated triathlon in space this past weekend on ISS.

After “swimming” half a mile (0.8 km), biking 18 miles (29 km), and running 4 miles (6.4 km), Williams finished with a time of one hour, 48 minutes and 33 seconds, she reported. The space station has its own treadmill and stationary bike, which use harnesses and straps in place of gravity to keep astronauts from floating away. To simulate the swimming portion of the race, Williams used what’s called the Advanced Resistive Exercise Device (ARED) to do weightlifting and resistance exercises that approximate swimming in microgravity.

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Over-the-counter osteoporosis drug appears to keep astronauts from losing bone density on long space flights

10:14 am

Big news: New research on ISS now shows that the standard over-the-counter osteoporosis drugs used by millions on Earth appears to keep astronauts from losing bone density during long space flights.

Beginning in 2009, the group administered the drug to five long-stay astronauts on the International Space Station (ISS), including Koichi Wakata, 48, and Soichi Noguchi, 46. The five took the drug — an over-the-counter bisphosphonate used to treat osteoporosis — once a week starting three weeks before they lifted off until they returned to Earth. The researchers then monitored the astronauts’ bone mass over time and compared the results to those for 14 astronauts that had never taken the drug.

The results showed that the 14 who had never taken the drug had average bone density loss of 7 percent in the femur, and 5 percent in the hip bone. The five astronauts on bisphosphonate, however, only had average bone density loss in the femur of 1 percent, and even a 3 percent increase in the hip bone. Calcium levels in their urine, which rise the more bone mass is lost, were also very low.

If these results hold up, they might very well solve one of the biggest challenges faced by any interplanetary traveler. Up until now, bone loss during long weightless missions never seemed to average less than 0.5 percent per month. After spending three years going to and from Mars, an astronaut could thus lose about almost 20 percent of their bone mass in their weight-bearing bones, and would probably be unable to return to Earth.

Thus, a mission to Mars seemed impossible, unless we could build a ship with some form of artificial gravity, an engineering challenge we don’t yet have the capability to achieve.

If these already tested drugs can eliminate this problem, then the solar system is finally open to us all. All that has to happen now is to do some one to two year manned missions on ISS to test the drugs effectiveness for these long periods of weightlessness.

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A new study has been released detailing the vision problems experienced by astronauts on space flights longer than six months

3:28 pm

A new study has been released detailing the vision problems experienced by astronauts on space flights longer than six months. Hat tip to Clark Lindsey.

The visual system changes discovered by the researchers may represent a set of adaptations to microgravity. The degree and type of response appear to vary among astronauts. Researchers hope to discover whether some astronauts are less affected by microgravity and therefore better-suited for extended space flight, such as a three-year round trip to Mars.

In their report, Drs. Mader and Lee also noted a recent NASA survey of 300 astronauts that found that correctible problems with both near and distance vision were reported by about 23 percent of astronauts on brief missions and by 48 percent of those on extended missions. The survey confirmed that for some astronauts, these vision changes continue for months or years after return to Earth.

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Eradicating polio: not this year

8:35 am

The effort to eradicated polio entirely by the end of 2012 will not be met.

Afghanistan and Nigeria, two of the three remaining endemic countries, have had more cases in the first nine months of this year than in 2010 altogether. Several other countries targeted by the plan have also seen more cases to date this year compared to this time in 2010. Additionally, polio had popped up in countries where it had previously been eradicated — notably China, which went polio-free for 11 years until this summer.

Sadly, politics and culture are almost certainly the main reasons polio still survives in these countries.

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Human bones taken to ISS for long space flight experiments.

11:13 pm

Human bones were part of the cargo on board the Soyuz capsule launched to ISS today.

“The fragments of human bones will be used to study the causes and dynamics of decalcination of bone tissue in a long space flight,” the head of the experiment, Tatiana Krasheninnikova told Itar-Tass. The problem of decalcination is a headache for medics responsible for spacemen’s health. Researches in this area are conducted by scientists from many ISS member states. However it is impossible to take sample of spacemen’s bones, only their urine is being examined, and a complete picture of dynamics of changes in human bones is not clear, she noted.

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