Tag: biology

ISS study suggests that weightlessness impacts the eyes of men more than women

10:50 am

Eye flattening while in space
Astronauts who experienced changes in their
eyes (SANS) while on long missions in space

The uncertainty of science: A recent study of 30 astronauts during long term stays on ISS suggests that weightlessness impacts the shape of the eyes more in men than in women.

You can read the paper here.

In addition to changes in fluid around the brain, the team also found that a form of eye compression, a hallmark of Spaceflight Associated Neuro-ocular Syndrome known as globe flattening, was the most consistent eye change among crew members. “By far the most prevalent sign of eye changes that we observed was globe flattening, suggesting that this should be the primary monitoring target for ocular health,” Seidler said. “Interestingly, eye changes were more prevalent in males than females.”

Globe flattening, when the back of the eyeball becomes slightly indented or pushed inward, might sound minor, but it can have significant effects on vision and raise concerns for long-duration space missions.

Surprisingly, there was no strong link between brain structural changes and eye changes, suggesting that the effects on the eyes and brain may arise from distinct mechanisms rather than shared physiological cause

For the eye research, the sample was so small, 28 individuals of which only 9 were females, the researchers readily admit in their abstract that and “interpretation of these findings should be tempered by the fact that our sample included a relatively small number of females.” Nonetheless, the research did suggest that, regardless of sex, about half of all humans will experience these eye issues during long missions in weightlessness.

The results underscore the need to do artificial gravity experiments in orbit, to find out the minimum amount of gravity needed to mitigate or even eliminate these health issues. Otherwise, interplanetary travel is going to be seriously hampered, if not impossible.

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New data raises doubts about exoplanet having chemicals that on Earth come from life

1:02 pm

The uncertainty of science: Using new data from the Webb Space Telescope, scientists now conclude that the identification on an exoplanet in April 2025 of the molecules dimethyl sulfide (DMS) and/or dimethyl disulfide (DMDS) — both of which on Earth are only associated with the presence of life — is now uncertain and that these molecules likely aren’t there.

The new work uses [Webb] data to better qualify what is going on. The work confirms the presence of an ocean on this peculiar exoplanet, although it can’t confirm if there is a thick or thin atmosphere. They couldn’t find water vapor in the atmosphere, suggesting that there is an efficient cold trap, keeping evaporation to a minimum on this temperate sub-Neptune world.

Those potential biosignatures were all below the threshold for an undeniable detection, and their model suggests that a possible presence of DMS could be explained by sources unrelated to life. They advise considering more and different molecules to use as biosignatures. Astronomers are studying worlds that are very different from our own, and the chemical signatures that seem obvious here on Earth might not fit well with those exoplanets.

In other words, they simply don’t have enough data to know, one way or the other. No surprise, The science of studying exoplanets is in its infancy, and right now can only tease out the smallest of details based on our limited technology and the distances involved.

You can read the new paper here [pdf]. It notes further that using these molecules as a sign of life is also a mistake, as they can be created in other ways having nothing to do with biology.

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Update on eye research at ISS

10:03 am

Link here. The NASA update provides a nice overview of the research, beginning with this overview:

When astronauts began spending six months and more aboard the International Space Station, they started to notice changes in their vision. For example, many found that, as their mission progressed, they needed stronger reading glasses. Researchers studying this phenomenon identified swelling in the optic disc, which is where the optic nerve enters the retina, and flattening of the eye shape. These symptoms became known as Space-Associated Neuro-Ocular Syndrome (SANS).

The research suspects the changes are due to the fluid shifts in the body that take place due to weightlessness, with blood shifting from the legs to the head. Various projects have studied a number of solutions, including wearing leg cuffs, administering vitamin B, and possibly using centrifuge-created artificial gravity to mitigate the condition. The problem has also generated new work in developing better equipment for to studying the eye, including improved imaging and techniques for measuring the eye’s stiffness.

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China reports discovery of new microbe on its Tiangong-3 space station

8:52 am

China’s state-run press yesterday announced the discovery of a new microbe on its Tiangong-3 space station that appears designed to survive in the harsh environment of space.

In May 2023, the Shenzhou-15 crew collected surface microbial samples using sterile wipes, preserving them at low temperatures in orbit. Subsequent ground analysis revealed the novel Niallia tiangongensis species, confirmed through multidisciplinary methods including morphological analysis, genome sequencing, phylogenetic studies and metabolic profiling, the CMSA said.

…Niallia tiangongensis demonstrates exceptional stress resistance, maintaining cellular redox balance and ensuring robust growth in extreme conditions by regulating bacillithiol (BSH) biosynthesis to counteract space-induced oxidative stress, according to the CMSA. It exhibits distinctive capabilities in biofilm formation and radiation damage repair, making it a highly adaptable “all-rounder” for space environments.

More information here. This new microbe has characteristics both different and similar to microbes found on ISS. Its discovery is also not that unique, a it appears such unusual and new biology has been found in other space-related environments, such as the clean rooms on Earth used to build spacecraft. For example, dozens were found in clean room for the Phoenix Mars lander in the early 2000s.

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First images ever of a live transparent colossal squid in its natural environment

10:45 am

Baby giant colossal squid
Click for original image.

Using an autonomous submersible, scientists have captured the first pictures and video ever of a live transparent colossal squid in its natural habitat.

This one was captured on film using a remotely operated vehicle at a depth of 1,968 feet (600 m) during the team’s 35-day expedition to uncover new marine life. It’s a juvenile squid, about 0.98 ft (30 cm) long, with a transparent body, iridescent eyes, trademark hooks on the middle of each of its eight arms, and clubs on its two long tentacles.

…If you’re looking at this and wondering why this colossal squid doesn’t resemble the hefty red one you saw being pulled aboard a fishing boat back in 2007, good eye! That’s because this species starts out transparent, and loses its see-through appearance as it ages. Dr Kat Bolstad, associate professor at the Auckland University of Technology Lab, noted that the red coloration seen in the arms suggests this creature could switch between looking transparent to opaque.

I have embedded the video below.
» Read more

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Researchers discover an anti-aging drug that extends the lives of rats 25%

9:49 am

Researchers have discovered that by blocking the increase of a certain protein within the body, they can not only extend the lives of rats by about 25%, the rats overall health in old age was improved significantly.

You can read the original paper here and the press release from the researchers here. From that press release:

After establishing IL11’s role in aging, the team demonstrated that by applying this anti-IL11 therapy in the same preclinical model, metabolism was improved. The mice shifted from generating white fat to beneficial brown fat. Brown fat breaks down blood sugar and fat molecules to help maintain body temperature and burn calories. The researchers also observed improved muscle function and overall better health in their study, as well as an increased lifespan by up to 5 per cent in both sexes.

Unlike other drugs known to inhibit specific pathways involved in aging, such as metformin and rapamycin, anti-IL11 therapy blocks multiple major signaling mechanisms that become dysfunctional with age, offering protection against cardio-metabolic diseases, age-related loss of muscle mass and strength as well as frailty. In addition to these externally observable changes, anti-IL11 therapy also reduced the rate of telomere shortening and preserved mitochondria’s health and ability to generate energy.

According the paper, this drug is now in early-stage clinical trials for fibrotic lung disease, but its benefits — as seen in these rat experiments — could turn out to be far greater, across the board.

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Research suggests a Mars mission will permanently damage a person’s kidneys

10:12 am

New research now suggests strongly that the exposure to cosmic rays during a three-year-long mission to Mars would cause permanent damage to a person’s kidneys.

The results indicated that both human and animal kidneys are ‘remodelled’ by the conditions in space, with specific kidney tubules responsible for fine tuning calcium and salt balance showing signs of shrinkage after less than a month in space. Researchers say the likely cause of this is microgravity rather than GCR [galactic cosmic rays], though further research is required to determine if the interaction of microgravity and GCR can accelerate or worsen these structural changes.

The primary reason that kidney stones develop during space missions had previously been assumed to be solely due to microgravity-induced bone loss that leads to a build-up of calcium in the urine. Rather, the UCL team’s findings indicated that the way the kidneys process salts is fundamentally altered by space flight and likely a primary contributor to kidney stone formation.

Perhaps the most alarming finding, at least for any astronaut considering a three-year round trip to Mars, is that the kidneys of mice exposed to radiation simulating GCR for 2.5 years experienced permanent damage and loss of function. [emphasis mine]

The study used samples “from over 40 Low Earth orbit space missions involving humans and mice, most of which were to the International Space Station, as well as 11 space simulations involving mice and rats.”

If these results are confirmed, it means that any interplanetary spaceship is going to require significant shielding. Having a safe haven they can go to during high energy solar events will not work, as cosmic rays arrive randomly at all times. This research thus tells us that we can’t simply add engines to the space station designs presently being built to send them to Mars. Instead, we need a heavy-lifte capability (such as Starship) to get the much heavier, well-shielded habitable modules into orbit.

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Scientists observe orangutan use plant to heal a wound

9:45 am

In what might be the most sophisticated medical treatement yet seen by a wild animal, scientists in 2022 observed an orangutan named Rakus treat a face wound with a poultice it made from a plant known by locals to have medicinal value.

Rakus was observed eating the stems and leaves of the creeper akar kuning (Fibraurea tinctoria), which local people use to treat diabetes, dysentery and malaria, among other conditions. Orangutans in the area rarely eat this plant.

In addition to eating the leaves, Rakus chewed them without swallowing and used his fingers to smear the juice on his facial wound over seven minutes. Some flies settled on the wound, whereupon Rakus spread a poultice of leaf-mash on the wound. He ate the plant again the next day. Eight days after his injury, his wound was fully closed.

Other animals have been seen using plants or insects for medicinal reasons, but none had done anything as complicated as Rakus. Nor have researchers of orangetans ever seen another do anything similar in more than two decades of research. It is thus unclear how Rakus knew what to do. Did he figure it out on the spot, or had he seen it done in the past by others when unobserved?

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Study: Long periods of weightlessness caused changes in the brain

9:55 am

Scientists studying the brains of 30 astronauts who spent from two weeks to one year on ISS have found that the longer a person stayed in weightlessness the greater the changes caused in the brain, and the longer it takes to recover.

Their findings, reported today in Scientific Reports, reveal that the brain’s ventricles expand significantly in those who completed longer missions of at least six months, and that less than three years may not provide enough time for the ventricles to fully recover.

Ventricles are cavities in the brain filled with cerebrospinal fluid, which provides protection, nourishment and waste removal to the brain. Mechanisms in the human body effectively distribute fluids throughout the body, but in the absence of gravity, the fluid shifts upward, pushing the brain higher within the skull and causing the ventricles to expand.

“We found that the more time people spent in space, the larger their ventricles became,” said Rachael Seidler, a professor of applied physiology and kinesiology at the University of Florida and an author of the study. “Many astronauts travel to space more than one time, and our study shows it takes about three years between flights for the ventricles to fully recover.”

You can read the paper here. The expansion of ventricles is a normal process due to aging, but I could not find any description in the paper noting its impact, for good or ill. Long periods of weightlessness brings it about quickly, but only temporarily.

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Study: Russian astronauts on ISS have better techniques for protecting the brain

9:12 am

According to a study comparing the changes in the brain experienced during long term missions on ISS, it appears that the Russians have developed better protocols for preparing themselves for return to Earth that prevents the enlargement in one part of the brain seen in American astronauts.

From the link:

The study focused on 24 Americans, 13 Russians, and a small, unspecified number of astronauts from the ESA. The researchers collected MRI scans of the astronauts’ brains before and after they spent six months on the ISS (only 256 individuals have visited the space station).

After being in space, all the space travelers exhibited similar brain changes: cerebrospinal fluid buildup and reduced space between the brain and the surrounding membrane at the top of the head. The Americans, however, also had more enlargement in the regions of the brain that serve as a cleaning system during sleep, e.g. the perivascular space (PVS).

…The Russian astronauts did not exhibit enlarged PVS, suggesting there might be differences in protocol that are neuro-protective.

From the paper itself:

[Russian C]osmonauts undergo six lower body negative pressure (LBNP) sessions starting two weeks prior to landing, while NASA and ESA astronauts do not typically do it. LBNP induces caudal displacement of fluids from the upper body by placing the legs and pelvis in a semiairtight chamber with negative pressure.

An advanced resistive exercise device (ARED) is regularly used by space flyers to perform free weight exercises on the ISS, but the load and frequency of use are lower for [Russian] cosmonauts compared with NASA and ESA astronauts. Lifting heavy loads during resistive exercise is often accompanied by a brief Valsalva maneuver, inducing increased ICP and decreased cerebral blood flow and cerebrovascular transmural pressure, which can result in PVS fluid accumulation. Although the effects of LBNP and ARED on the brain during spaceflight are unknown, they could partly explain the different WM-PVS changes detected in astronauts and cosmonauts. We cannot exclude that other factors (e.g., diet) might play a role in this difference. Further studies are required to confirm these hypotheses.

Apparently two protocols are different that seem to help the Russians. First, the LBNP, developed by the Russians on their earlier space stations, is essentially a pair of pants that sucks fluids down to the legs, simulating the situation normally found on Earth, and thus reduces the fluids in the upper body sooner than landing. Second, doing exercises simulating lower weight loads apparently helps the Russians as well.

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Russian researchers: ISS home to more than 20 types of microorganisms

8:59 am

After studying more than 200 samples from ISS brought back to Russia, researchers have identified more than 20 types of microorganisms that make their home on ISS, including some pathogens and fungi.

The habitat of the module and the entire Russian segment of the ISS is an environmental niche home to bacteria and microscopic fungi, the materials suggest. “These microorganisms use the station’s decorative-finishing and design materials as their basic habitat,” according to the materials.

The experiment aboard the ISS involved taking samples and delivering them to Earth in descent modules. In the course of three years, over 200 samples were taken, with bacteria discovered in 34% and fungi in 3% of them. “In 5% of the samples with the presence of bacterial microflora and in 100% of the samples with the presence of fungal microflora, the standard indicator regulated by SSP 50260 NORD was exceeded,” the materials say.

The fungi indicate mold, a long known problem on manned space stations first identified by the Russians on their Salyut stations in the ’70s and ’80s. The pathogens do not appear to be harmful, or else the astronauts would have experienced sicknesses. No such sicknesses have been reported, though they might have occurred but have not been released publicly due to medical privacy concerns.

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Study: Weightlessness might produce long term anemia

3:13 pm

The uncertainty of science: A study of fourteen astronauts who spent six months on ISS has found that weightlessness appears to increase the loss of red blood cells, and that the continuing loss extends well past their return to Earth.

Before this study, space anemia was thought to be a quick adaptation to fluids shifting into the astronaut’s upper body when they first arrived in space. Astronauts lose 10 percent of the liquid in their blood vessels this way. It was thought astronauts rapidly destroyed 10 percent of their red blood cells to restore the balance, and that red blood cell control was back to normal after 10 days in space.

Instead, Dr. Trudel’s team found that the red blood cell destruction was a primary effect of being in space, not just caused by fluid shifts. They demonstrated this by directly measuring red blood cell destruction in 14 astronauts during their six-month space missions.

On Earth, our bodies create and destroy 2 million red blood cells every second. The researchers found that astronauts were destroying 54 percent more red blood cells during the six months they were in space, or 3 million every second. These results were the same for both female and male astronauts.

The study also found that for as much as a year afterward the astronauts continued to lose red blood cells at a rate 30% greater than normal.

The researchers immediately suggested further invasive monitoring of anyone who wants to go to space. From their paper:

Space tourism will considerably expand the number of space travelers. Medical screening of future astronauts and space tourists might benefit from a preflight profiling of globin gene and modifiers. Postlanding monitoring should cover conditions affected by anemia and hemolysis. Monitoring individual astronaut’s levels of hemolysis during mission may be indicated to reduce health risks.

Without question, this data strongly suggests that it would be wise for anyone who wants to go into space for long periods have themselves checked for anemia, and have it treated prior to going, or if they still have it at launch time to decide not to go. However, the choice should belong to the individual, not bureaucrats imposing regulations or legislators passing laws.

Unfortunately, our modern leftist society now assumes such decisions no longer belong to the individual, but must be made by their betters in Washington. Provisions in the 2004 Space Amendments act allows the FAA to impose such invasive medical testing on future space tourists. Its bureaucrats have not yet done so, but the recent history with government mandates over the COVID shots suggests strongly that they will not hesitate to do so when they think they can get away with it.

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Astronaut blood samples suggest long-term exposure to weightlessness causes brain damage

2:10 pm

New research comparing blood samples taken from five Russian astronauts before and after long term missions to ISS suggests that weightlessness can cause brain damage.

Published in JAMA Neurology, the new research looked at five male Russian cosmonauts. Each spent an average of 169 days in space. Blood samples were taken from each subject before leaving Earth, and then at three points after returning.

Five different blood-based biomarkers were measured, each known to correlate with some kind of brain damage. Three biomarkers in particular were found to be significantly elevated after the cosmonauts returned to Earth – neurofilament light (NfL), glial fibrillary acidic protein (GFAP), and a specific type of amyloid beta protein.

The researchers hypothesize the increases in NfL and GFAP levels may indicate a type of neurodegeneration called axonal disintegration. Elevated NfL levels are currently being investigated as a way of detecting the earliest stages of brain damage associated with Alzheimer’s disease.

It must be emphasized that the research did not find brain damage, only data within the blood samples that is often associated with brain damage. More research is required to determine if these biomarkers indicate the same thing in space as they do on Earth.

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Study: U.S. mortality rates suggest background radiation actually beneficial

9:10 am

The uncertainty of science: According to a new study by researchers at Ben-Gurion University in Israel of mortality rates across the entire United States, people that live in regions of higher background radiation have lifespans on average 2.5 years longer.

Background radiation is an ionizing radiation that exists in the environment because of natural sources. In their study, BGU researchers show that life expectancy is approximately 2.5 years longer among people living in areas with a relatively high vs. low background radiation. Background radiation includes radiation emanating from space, and radiation from terrestrial sources. Since the 1960s, there has been a linear no-threshold hypothesis guiding policy that any radiation level carries some risk. Hundreds of billions of dollars are spent around the world to reduce radiation levels as much as possible.

…According to BGU Professors Vadim Fraifeld and Marina Wolfson, along with Dr. Elroei David of the Nuclear Research Center Negev, lower levels of several types of cancers were found when the radiation levels were on the higher end of the spectrum rather than on the lower end. Among both men and women, there was a significant decrease in lung, pancreatic, colon and rectal cancers. Among men, there were additional decreases in brain and bladder cancers. There was no decrease in cervix, breast or prostate cancers or leukemia.

Their data “covered the entire US population of the 3139 US counties, encompassing over 320 million people,” according to their paper’s abstract.

Up until now the assumption has been that any radiation is bad, based not on research but on assumptions gained by the negative consequence of exposure to high radiation. There has been no good data on the consequences of low level background radiation, because it is so hard to gather. The time frames are long and the numbers small, all of which causes the impact of background radiation to be overwhelmed by other factors. This study’s statistical use of the entire U.S. population is an attempt to overcome these obstacles.

This study is statistical, which means it found a correlation between higher radiation and longer lifespans. Correlation however does not prove causation. The study found no direct evidence that humans health benefits from background radiation. We should therefore take these results with a large grain of salt.

At the same time, their extremely large database is quite telling, and adds some weight to their conclusion.

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New changes to the brain found from long space missions

8:38 am

Scientists have discovered a “significant increase” in the brain’s white matter that occurs after astronauts have completed long missions in weightlessness.

The team conducted brain MRIs of 11 astronauts before they traveled to the ISS, and then again one day after they returned. Scans were then performed at several interval across the following year. “What we identified that no one has really identified before is that there is a significant increase of volume in the brain’s white matter from preflight to postflight,” Kramer says. “White matter expansion in fact is responsible for the largest increase in combined brain and cerebrospinal fluid volumes postflight.”

These changes remained visible one year after spaceflight, which the researchers say indicates they could be permanent alterations. Past research has suggested that changes in the volume of cerebrospinal fluid (CSF) specifically could be a key driver of Visual Impairment Intracranial Pressure in astronauts. The authors of the new study also observed an increase in the velocity of CSF through the cerebral aqueduct, along with deformation of the pituitary gland, which they believe is related to higher intracranial pressure in microgravity.

The uncertainties for this work remain very large. For one thing, the sample (11 astronauts) is very small. For another, the permanence of this change is only suggested and remains unproven.

Nonetheless, this research adds to the growing body of research that suggests that long term weightlessness is generally not good for the human body. It also reinforces the desperate need for research into the effects of even a small amount of artificial gravity. To most efficiently design spacecraft that provide some form of centrifugal force as artificial gravity, we need to find out the minimum required. It could be providing only 10% or 30% Earth gravity could be sufficient. Or not. We just don’t know.

The engineering challenges however go up significantly the more gravity you need to create. For future interplanetary travel this information is critical.

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French and American studies find drug that can treat COVID-19

10:00 pm

It isn’t a vaccine that will prevent infection, but tests in France and in the U.S. now show that a drug normally used to treat malaria is very effective in reducing the symptoms of the Wuhan virus.

He said that the first Covid-19 patients he had treated with the drug chloroquine had seen a rapid and effective speeding up of their healing process, and a sharp decrease in the amount of time they remained contagious.

Chloroquine – which is normally used mainly to prevent and treat malaria – was administered via the named drug, Plaquenil.

The drug is readily available and can be prescribed to anyone who is considered threatened by the virus to help them get better why reducing the chances of them giving it to others.

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Coronavirus update

9:35 am

Link here. In the past five days the number of people known to be infected has grown from about 450 to now more than 1,400, with deaths rising to 41 total. (The rate of deaths to those infected however has dropped, from 5% to less than 1%.) Also, a very small number of cases have been found in other countries throughout the world, limited so far to people who had recently been in the region of China with the most infections.

How serious is this epidemic? The rise in cases in only a week is concerning for sure, as very quickly the numbers are beginning to match the SARS epidemic in 2002-2003, which took a year to get to 8,000 infected. The so-far low death rate however suggests the disease is manageable.

The situation in China however is very serious. They have locked down regions with populations in the multi-millions, and the number of cases might soon strain their health system. Worse, we do not know if the numbers the non-transparent communist government is posting are accurate. There have been numerous rumors all week that the infection count is far higher than what has been publicly revealed. This could be true, or not. The rumors exist because no one trusts the communists to allow the truth to be published.

At the moment it still appears to me that, at least outside of China, the situation is under control. Whether it remains that way we can only wait and see.

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Does zero gravity cause intestinal issues?

9:23 am

The uncertainties of science: New research simulating microgravity on Earth now suggests that zero gravity might weaken the walls of the intestines.

The barrier function of the intestinal epithelium, he added, is critical for maintaining a healthy intestine; when disrupted, it can lead to increased permeability or leakiness. This, in turn, can greatly increase the risk of infections and chronic inflammatory conditions such as inflammatory bowel disease, celiac disease, Type 1 diabetes, and liver disease.

McCole’s team used a rotating wall vessel — a bioreactor that maintains cells in a controlled rotation environment that simulates near weightlessness — to examine the impact of simulated microgravity on cultured intestinal epithelial cells.

Following culture for 18 days in the vessel, the team discovered intestinal epithelial cells showed delayed formation of “tight junctions,” which are junctions that connect individual epithelial cells and are necessary for maintaining impermeability. The rotating wall vessel also produces an altered pattern of tight junction assembly that is retained up to 14 days after the intestinal epithelial cells were removed from the vessel.

This is good research, but it has not proved anything, merely indicated an area of research that needs a follow-up in space. I also wonder if there has been any evidence of this phenomenon from astronauts returning from long missions. As far as I know, intestinal issues have never been mentioned as a problem post flight.

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Charles Walker: the first commercial astronaut

12:23 pm

Charles Walker on the Space Shuttle in November 1985

Last night I attended another one of the monthly Arizona Space Business Roundtable events held here in Tucson to bring together the business-oriented space community of this city.

The speaker was Charles Walker, who had flown three shuttle missions in 1984 and 1985, but not as a NASA-employed astronaut but as an employee of McDonnell-Douglas, making him the first astronaut to fly in space under the employ of a private commercial company.

Walker’s job then was to monitor and maintain a drug-processing unit designed to produce large quantities of pure biological hormones that on Earth were simply not possible. Gravity polluted the process, while weightlessness acted to purify things. If successful the hormone produced could be sold to fight anemia, especially in individuals taking radiation treatments. The image on the right shows him on his third and last shuttle mission, launched November 26, 1985. He is working with a handheld protein crystal growth experiment, with the larger hormone purifying experiment on the wall behind this.

According to Walker’s presentation yesterday, this third flight in November 1985 demonstrated the process worked and could produce as much as one liter of hormone, enough to easily make back the cost of the project and leave room for an acceptable profit. They were thus ready for fullscale production on future shuttle flights, only to have the entire project die when the Challenger shuttle was lost on January 28, 1986. With that failure President Reagan declared that the shuttle would no longer be used for commercial flights.

Their business plan had been dependent on the artificially low launch prices NASA had been charging them for shuttle flights. Without the shuttle there was then no affordable alternative for getting into orbit.

The process is still viable, and the need for these drugs still exists. Whether they could now be flown on the new cheaper private rockets, on board future private space stations like Bigelow’s B330, remains unknown. A new company would have to pick up the pieces, as McDonnell-Douglas no longer exists, having been absorbed into Boeing.

I personally suspect there is real money to be made here, should someone decide to go for it.

What struck me most while watching Walker speak was the same thing that has struck me whenever I have seen or interviewed any astronaut: He appeared to be such an ordinary down-to-earth human being. He could have been anyone you meet anywhere.

What made him stand out, as he described his upbringing and how he became an astronaut, was not his intelligence or any physical attribute, but his clear willingness to stay focused on his goals, to work has hard as possible to make them come true. What made him succeed was an unwavering commitment. He wanted to get to space, and by gum he was going to do it!

Charles Walker on first flight, August 1984
Walker on his first flight in 1984.

For example, he was too young to fly in the initial space race in the 1960s. When he finally was old enough and ready in the 1970s, NASA’s space program was being shut down. That option seemed dead. So instead, he began looking for another route into space, and found it with private industry and possibility of making money by using weightlessness to produce medicines in space that could not be produced on Earth.

Obviously, luck is always a factor. Had his project been a little delayed, only a year, it would have never flown, and he would never have gone into space. Similarly, he needed to be in the right place at the right time to get this particularly job in the first place.

At the same time, “Luck is a residue of design,” as said by Branch Rickey, general manager of the Brooklyn Dodges in the 1950s. Walker didn’t give up when the Apollo program died in the 1970s, and thus he put himself in the right place at McDonnell-Douglas when this opportunity arose.

We should all pay close attention. If you have a dream, you need to follow it, with a fearless wholehearted commitment. If you do, you still might not get it as you dreamed, but you will increase your chances, and regardless, you will end up doing far better for yourself and everyone around you.

And you still might end up like Walker, bouncing around in weightlessness out in the vast reaches of outer space.

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Study says space radiation less of a risk

9:05 am

A newly released study now claims that, based on a long term review of astronauts who have spent a considerable time in space, it appears that space radiation does not cause an increase in cancer later in life.

The new study analyzed information from 418 space travelers, including 301 NASA astronauts who had traveled to space at least once since 1959, and 117 Russian or Soviet cosmonauts who had traveled to space at least once since 1961. These participants were followed for about 25 years, on average.

During this time, 89 of the participants died. Among the 53 NASA astronauts who died, 30% died from cancer and 15% from heart disease; while among the 36 Russian or Soviet cosmonauts who died, 50% died from heart disease and 28% from cancer.

The researchers used a special statistical technique to determine whether deaths from cancer and heart disease likely had a common cause — in this case, the common cause would be space radiation. But their results did not point to a common cause of death. “If ionizing radiation is impacting the risk of death due to cancer and cardiovascular disease, the effect is not dramatic,” the authors wrote in their study, published July 4 in the journal Scientific Reports.

This story first appeared about two weeks ago, but I didn’t think it significant, and still don’t. The sample is just not large enough to draw any solid conclusions. Moreover, this is exposure in low Earth orbit, not on interplanetary missions where the radiation risk is higher. It would be a big mistake for future space engineering to accept these findings blindly.

Still, news reports keep popping up about it, and I decided I should at least note it here on Behind the Black.

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Mold in space can tolerate very high doses of radiation

9:15 am

New research has discovered that the mold found on the International Space Station is able to tolerate very high doses of radiation.

Spores of the two most common types of mold on the ISS, Aspergillus and Pennicillium, survive X-ray exposure at 200 times the dose that would kill a human, according to Marta Cortesão, a microbiologist at the German Aerospace Center (DLR) in Cologne, who will present the new research Friday at the 2019 Astrobiology Science Conference (AbSciCon 2019).

Pennicillium and Aspergillus species are not usually harmful, but inhaling their spores in large amounts can sicken people with weakened immune systems. Mold spores can withstand extreme temperatures, ultraviolet light, chemicals and dry conditions. This resiliency makes them hard to kill.

“We now know that [fungal spores] resist radiation much more than we thought they would, to the point where we need to take them into consideration when we are cleaning spacecraft, inside and outside,” Cortesao said. “If we’re planning a long duration mission, we can plan on having these mold spores with us because probably they will survive the space travel.”

While these findings likely mean an increase in the cost for sterilizing future planetary probes, they also mean that fungi will be available for future space travelers for the production of antibiotics, food, and other useful items.

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Nearly 400 medical procedures found to be ineffective

3:32 pm

The uncertainty of science: A new review of the science literature has found almost 400 studies showing the ineffectiveness of the medical procedure or device they were studying.

The findings are based on more than 15 years of randomised controlled trials, a type of research that aims to reduce bias when testing new treatments. Across 3,000 articles in three leading medical journals from the UK and the US, the authors found 396 reversals.

While these were found in every medical discipline, cardiovascular disease was by far the most commonly represented category, at 20 percent; it was followed by preventative medicine and critical care. Taken together, it appears that medication was the most common reversal at 33 percent; procedures came in second at 20 percent, and vitamins and supplements came in third at 13 percent.

A reversal means that the study found the procedure, device, or medicine to be ineffective.

If you have medical issues it is worth reviewing the research itself. You might find that some of the medical treatment you are getting is irrelevant, and could be discontinued.

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Possible cure for AIDS?

9:17 pm

In the past week researchers have revealed that two different patients have apparently had the AIDS HIV virus eliminated from their bodies.

The virus infects cells of the immune system, which are made in the bone marrow. A man known as the “Berlin patient” was the first person to become HIV-free after cancer treatment, back in 2007. To treat his leukaemia – a cancer of the immune system – he was given a treatment that involved killing nearly all his immune cells with radiotherapy or drugs, and then replacing them with cells from a donor. This donor was naturally resistant to HIV, thanks to a rare but natural mutation in a gene called CCR5.

Since then, no one else had had HIV eliminated from their body in the same way, until a second case was announced on Monday. This person, known as the London patient, was given bone marrow from a donor with the CCR5 mutation as a treatment for Hodgkin’s lymphoma, another immune cell cancer. He was advised to stop taking the antiviral drugs that keep the virus in check about a year afterwards. Eighteen months later, the virus hasn’t returned.

A possible third case was then announced today, at the Conference on Retroviruses and Opportunistic Infections in Seattle.

The more than dozen year gap between the first cure and the two this week is partly because it takes so long to perform the treatment and then confirm the virus is gone. Moreover, this treatment can only be given to a limited number of patients, because of the risks involved.

Nonetheless, if this cure is proven viable, it will be a great triumph for modern science.

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Potentially dangerous bacteria found on ISS

9:24 am

Researchers have found five strains of bacteria on ISS that, while not dangerous now, has the potential to mutate into forms that could be a threat.

When Bezdan and colleagues ran the numbers on the space station microbes, however, they found that they were similar to only three – and rare ones, at that. They report similarities with strains found to date only once – one recovered from neonatal blood in a Tanzanian patient, another from a neonatal urine sample in the US, and the third from a 72-year-old woman with multiple health problems. In total, the researchers report, the eight strains thus “formed a unique ecotype”.

The ISS strains all contained genes associated with drug-resistance. They did not, however, contain combinations associated with high infection rates. Nevertheless, the results are enough for the researchers to sound a warning.

There are a lot of uncertainties here, including a lack of understanding of the effect of weighlessness on these bacteria. Nonetheless, this research highlights an important problem for future interplanetary spacecraft that has generally been ignored: Their small and limited ecology is very vulnerable to this kind of threat.

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Scientists identify molecule linked to anti-aging effects

2:18 pm

Scientists have identified a molecule produced by the body during fasting that then acts to delay aging.

In this study, the research team explores the link between calorie restriction (eating less or fasting) and delaying aging, which is unknown and has been poorly studied. The findings are published in the journal Molecular Cell.

The researchers identified an important, small molecule that is produced during fasting or calorie restriction conditions. The molecule, β-Hydroxybutyrate, is one type of a ketone body, or a water-soluble molecule that contains a ketone group and is produced by the liver from fatty acids during periods of low food intake, carbohydrate restrictive diets, starvation and prolonged intense exercise.

“We found this compound, β-Hydroxybutyrate, can delay vascular aging,” Zou said. “That’s actually providing a chemical link between calorie restriction and fasting and the anti-aging effect. This compound can delay vascular aging through endothelial cells, which line the interior surface of blood vessels and lymphatic vessels. It can prevent one type of cell aging called senescence, or cellular aging.”

Senescent cells can no longer multiple and divide. The researchers found β-Hydroxybutyrate can promote cell division and prevent these cells from becoming old. Because this molecule is produced during calorie restriction or fasting, when people overeat or become obese this molecule is possibly suppressed, which would accelerate aging.

It appears that there is still a lot of work to create an artificially produced version of this molecule, but to know it exists is a significant discovery. For the body to produce it requires you to fast for at least 24 hours.

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Two roundworms return to life after being frozen for almost 42,000 years

10:25 am

Russian scientists have successfully brought two roundworms back to life after being frozen for almost 42,000 years.

Russian scientists said the two prehistoric worms, out of a group of about 300, are moving and eating after they came back to life in a lab at the Institute of Physico-Chemical and Biological Problems of Soil Science in Moscow, the Siberian Times reported. “After being defrosted, the nematodes showed signs of life,” a report from the Russian scientists said, according to the Siberian Times.

One of the worms was found near the Alazeya River in 2015 and is believed to be about 41,700 years old, according to the study published in the Doklady Biological Sciences. They were found about 11.5 feet underground.

The other worm was found in 2002 in a fossil rodent burrow near the Kolyma River. These samples were taken from about 100 feet underground.

If confirmed, this result is not only astonishing, it has significant implications, as it suggests that the science fiction idea of freezing people for long interstellar flights might actually be possible, eventually.

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Complex carbon molecules from within Enceladus

9:11 am

Scientists have determined, using Cassini data, that there are complex carbon molecules spewing from the tiger stripes on Saturn’s moon Enceladus.

Putting it all together, the scientists concluded that the Cassini spacecraft was encountering dust particles rich in carbon in large, complex “macromolecular structures”. The only place this material could have come from was the interior of Enceladus, from which ice, dust and gas is jetting out in geyser-like plumes. These plumes are fed by vapours escaping from a sub-surface ocean.

“So this is a direct sample of the Enceladus ocean,” Khawaja says.

What exactly the newly discovered organic materials are is open for debate, although Khawaja believes they most likely are made of large numbers of ring-like structures cross-linked by hydrocarbon chains. An important hint comes from the fact that the organic-rich grains don’t contain much water, implying that the materials in them don’t easily mix with water. Khawaja hypothesises that they formed deep inside Enceladus, then rose to the top of its underwater ocean, where they formed a thin film akin to an earthly oil slick.

Just to be very clear, they have not discovered life. What they have found however increases the chances that there is life within Enceladus’s underground ocean.

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Curiosity finds methane fluctuates seasonally in Gale Crater

9:05 am

Seasonal methane on Mars

In its second significant science release yesterday (the first relating to the discovery of organics), the Curiosity science team revealed that they have found over almost three Martian years the amount of methane in the atmosphere appears to fluctuate seasonally. The graph on the right illustrates this change.

[The data] show methane rises from just above 0.2ppb in the northern hemisphere winter to a fraction over 0.6ppb in the summer. The team’s best explanation is that methane is seeping up from underground, perhaps from stored ices, and is then being released when surface soils are warmed.

The team cannot positively identify the origin of the methane, but the researchers think they can close down one particular mechanism for its production. This involves sunlight breaking up carbon-rich (organic) molecules that have fallen to the planet’s surface in meteorites.

The variation in ultraviolet light over the course of the seasons is not big enough to drive the scale of the change seen in the methane concentration, says Dr Webster. “We know the intensity of the Sun and this mechanism should produce only a 20% increase in methane during the summer, but we’re seeing it increase by a factor of three,” he explained.

The change could be caused by either a chemical or a biological process. At this time there is no way to determine which.

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Certain microbes survive in clean rooms by eating the cleaning fluids

10:51 pm

Researchers have found that the reason certain microbes seem to survive in all spacecraft clean rooms is that those microbes actually live off the very cleaning fluids used to scrub the rooms.

Despite extensive cleaning procedures, however, molecular genetic analyses show that the clean rooms harbor a diverse collection of microorganisms, or a spacecraft microbiome, that includes bacteria, archaea and fungi, explained Mogul. The Acinetobacter, a genus of bacteria, are among the dominant members of the spacecraft microbiome.

To figure out how the spacecraft microbiome survives in the cleanroom facilities, the research team analyzed several Acinetobacter strains that were originally isolated from the Mars Odyssey and Phoenix spacecraft facilities.

They found that under very nutrient-restricted conditions, most of the tested strains grew on and biodegraded the cleaning agents used during spacecraft assembly. The work showed that cultures grew on ethyl alcohol as a sole carbon source while displaying reasonable tolerances towards oxidative stress. This is important since oxidative stress is associated with desiccating and high radiation environments similar to Mars.

The tested strains were also able to biodegrade isopropyl alcohol and Kleenol 30, two other cleaning agents commonly used, with these products potentially serving as energy sources for the microbiome.

With this information, the space engineering community will be able to refine their clean room operations to eliminate these microbes so as to better sterilize spacecraft heading on life-seeking missions.

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