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Good news! NASA today announced that recent research on ISS into bone loss due to weightlessness has found that proper exercise and diet can stabilize bone loss.
Past Russian research on Mir had found that exercise and diet could limit the bone loss, but not stop it entirely. The key difference in this recent work seems to be the use of more sophisticated exercise equipment.
If this research holds up, it eliminates one of the most serious obstacles to interplanetary travel.