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It looks like there will be no manned Soyuz missions launched from South America.
An ESA study conducted between 2002 and 2004 found that because the Soyuz has not been designed to land in the sea, a French Guiana launch that had to be aborted would endanger the spacecraft and its crew as it would likely have to ditch in the Atlantic Ocean. The Soyuz spacecraft have always landed on land in the former Soviet territory of Kazakhstan.