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The number one injury reported by astronauts appears to be fingernail and hand injuries resulting from the use of spacesuit gloves. Key quote:
A previous study of astronaut injuries sustained during spacewalks had found that about 47 percent of 352 reported symptoms between 2002 and 2004 were hand related. More than half of these hand injuries were due to fingertips and nails making contact with the hard “thimbles” inside the glove fingertips. In several cases, sustained pressure on the fingertips during EVAs caused intense pain and led to the astronauts’ nails detaching from their nailbeds, a condition called fingernail delamination.