Using fish to study bone loss in weightlessness
A Japanese experiment on ISS, comparing the development of fish in weightlessness with those on the ground, has provided` scientists more information about bone density loss in weightlessness.
Akira Kudo at Tokyo Institute of Technology, together with scientists across Japan, have shown that medaka fish reared on the International Space Station for 56 days experienced increased osteoclast activity – bone cells involved in the re-absorption of bone tissue – likely leading to a subsequent reduction of bone density. They also found several genes that were upregulated in the fish during the space mission. The team generated fish with osteoclasts that emit a fluorescent signal. They sent 24 fish into space as juveniles, and monitored their development for 56 days under microgravity. The results were compared with a fish control group kept on Earth.
Kudo and his team found that bone mineral density in the pharyngeal bone (the jaw bone at the back of the throat) and the teeth of the fish reduced significantly, with decreased calcification by day 56 compared with the control group. This thinning of bone was accompanied by an increase in the volume and activity of osteoclasts. The team conducted whole transcriptome analysis of the fish jaws, and uncovered two strongly upregulated genes (fkbp5 and ddit4), together with 15 other mitochondria-related genes whose expression was also enhanced. Reduced movement under microgravity also has an influence. The fish began to exhibit unusual behavior towards the latter stages of their stay in space, showing motionless at day 47.
What the data mostly confirms is that long-term weightlessness is a bad thing for the development of bones, and not just in humans. Whether scientists can use these results to counter these harmful effects is not clear, however.
On Christmas Eve 1968 three Americans became the first humans to visit another world. What they did to celebrate was unexpected and profound, and will be remembered throughout all human history. Genesis: the Story of Apollo 8, Robert Zimmerman's classic history of humanity's first journey to another world, tells that story, and it is now available as both an ebook and an audiobook, both with a foreword by Valerie Anders and a new introduction by Robert Zimmerman.
The print edition can be purchased at Amazon or from any other book seller. If you want an autographed copy the price is $60 for the hardback and $45 for the paperback, plus $8 shipping for each. Go here for purchasing details. The ebook is available everywhere for $5.99 (before discount) at amazon, or direct from my ebook publisher, ebookit. If you buy it from ebookit you don't support the big tech companies and the author gets a bigger cut much sooner.
The audiobook is also available at all these vendors, and is also free with a 30-day trial membership to Audible.
"Not simply about one mission, [Genesis] is also the history of America's quest for the moon... Zimmerman has done a masterful job of tying disparate events together into a solid account of one of America's greatest human triumphs."--San Antonio Express-News
A Japanese experiment on ISS, comparing the development of fish in weightlessness with those on the ground, has provided` scientists more information about bone density loss in weightlessness.
Akira Kudo at Tokyo Institute of Technology, together with scientists across Japan, have shown that medaka fish reared on the International Space Station for 56 days experienced increased osteoclast activity – bone cells involved in the re-absorption of bone tissue – likely leading to a subsequent reduction of bone density. They also found several genes that were upregulated in the fish during the space mission. The team generated fish with osteoclasts that emit a fluorescent signal. They sent 24 fish into space as juveniles, and monitored their development for 56 days under microgravity. The results were compared with a fish control group kept on Earth.
Kudo and his team found that bone mineral density in the pharyngeal bone (the jaw bone at the back of the throat) and the teeth of the fish reduced significantly, with decreased calcification by day 56 compared with the control group. This thinning of bone was accompanied by an increase in the volume and activity of osteoclasts. The team conducted whole transcriptome analysis of the fish jaws, and uncovered two strongly upregulated genes (fkbp5 and ddit4), together with 15 other mitochondria-related genes whose expression was also enhanced. Reduced movement under microgravity also has an influence. The fish began to exhibit unusual behavior towards the latter stages of their stay in space, showing motionless at day 47.
What the data mostly confirms is that long-term weightlessness is a bad thing for the development of bones, and not just in humans. Whether scientists can use these results to counter these harmful effects is not clear, however.
On Christmas Eve 1968 three Americans became the first humans to visit another world. What they did to celebrate was unexpected and profound, and will be remembered throughout all human history. Genesis: the Story of Apollo 8, Robert Zimmerman's classic history of humanity's first journey to another world, tells that story, and it is now available as both an ebook and an audiobook, both with a foreword by Valerie Anders and a new introduction by Robert Zimmerman.
The print edition can be purchased at Amazon or from any other book seller. If you want an autographed copy the price is $60 for the hardback and $45 for the paperback, plus $8 shipping for each. Go here for purchasing details. The ebook is available everywhere for $5.99 (before discount) at amazon, or direct from my ebook publisher, ebookit. If you buy it from ebookit you don't support the big tech companies and the author gets a bigger cut much sooner.
The audiobook is also available at all these vendors, and is also free with a 30-day trial membership to Audible.
"Not simply about one mission, [Genesis] is also the history of America's quest for the moon... Zimmerman has done a masterful job of tying disparate events together into a solid account of one of America's greatest human triumphs."--San Antonio Express-News
We should do no more of these studies until we conduct a tether and spin-up experiment. If successful, this experiment might, to a large degree negate the innumerable studies of the negative health effects of zero-gee.
Bone loss for humans who plan to return to a 1G environment is a problem. We will have to devise a solution or a work-around to overcome it. I prefer to look at all new extraterrestrial knowledge through rose colored serendipity glasses.
The million dollar question is:
Can boneless fish be bred in microgravity?
What a great source of protein for exploration expeditions as well as the inevitable asteroid miners!